Anyone on the Ascend Plus trial?

Partsman991

Newbie
Messages
1
Type of diabetes
Type 2
Treatment type
Diet only
Hi,
I have just started on 3mg.
How can you tell if on a placebo? Thought even placebo bottles have Semaglutide printed on them.
I have had no side effects as yet and definitely no changes to appetite (feeling full).
How is your treatment so far?.
As I understand things, everyone is on the real semaglutide during the run in period. After that it's 50/50. I have just started my second batch of 6 months supply and I am pretty convinced that I'm on the real thing. I did get the stomach problems for the first couple of months on the 14mg tablets then all the side effects dissappeared except one. For the last 30 or so years I was getting through between 1 or 2 bottles of vodka a week but since I started this trial I have absolutely no interest in alcohol at all. Can't even finish a pint of beer when out for family meals. Also I've lost nearly 3 stone, 2 trouser sizes and my hba1c figure last week was down to 39 (from 52).
 
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Reactions: nursel
Messages
2
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.

Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?
 
Messages
2
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.

Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?
I'm hoping to start this trial soon, but am hav8ng trouble finding out from my insurance company whether it will affect my travel insurance. A doctor from the trial I spoke to today said some people had to drop out because of their travel insurance being affected. Had anyone had experience of this?
 

COCO26

Member
Messages
22
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Dislikes
Unhealthy habits that can easily impact on your overall health
Doyou know what the x means? Th3re is an x on my bottle of tablets
Hi did you find out what ‘x’ means on the bottles? My bottles have it too. Thanks
 

Sally66

Well-Known Member
Messages
77
Type of diabetes
Prediabetes
Treatment type
Diet only
Hi fellow participants.

I have just emailed Ascend Plus to explain what happened when I started the randomisation phase over a year ago now. I’m certain I’m on the placebo. I had immediate rebound weight gain and higher than my usual BS levels despite same low carb diet. Since then weight management has been a massive struggle.

I initially lost 2 stone after diagnosis just through exercise and low carb. The “run in” Semaglutide on the trial helped me maintain this and lose a little more. Since being on the placebo (I am certain I am) I’ve regained a stone, BS gone back to pre-diabetes range (got back to normal before). Psychologically it has really got to me. I swim 1km a day 5 times a week, control my carbs carefully (so low carb diet) and have even reduced to just two meals a day.

So fed up by the weight gain that I’m going to go back to the diabetic team at my GP surgery to talk about it. I doubt very much they will agree to prescribing any weight loss drugs and I just can’t afford to pay.

I have been on antidepressants for over a decade and I’m at the final weaning off stage. The last thing I want is them saying I stay on them and just exercise more and reduce calories further! I’m 58, there are limits to how much exercise I can do.

Like others, experiencing the same, I’m so disappointed. I really saw this trial as a way to help me and feel totally cheated. I understand that scientific trials need some on a placebo but so ****** off that had to be me!
 

Sally66

Well-Known Member
Messages
77
Type of diabetes
Prediabetes
Treatment type
Diet only
Do you really think it’s aspirin the placebo? wow! I never thought of that.you are right about pricking fingers and bleeding. I also bruised very easily now. I just thought the placebo would be a “nothing” tablet. Now I think you may be right. I’ll let you know how I get on with the diabetic nurse requesting weight loss Semaglutide, going to argue my case but don’t have a lot of hope.