Anyone on the Ascend Plus trial?

Mrs Redboots said:

I got so fed up of having to wake up at 06:30 to take my tablet that last night I did a bit of research on-line and discovered several peer-reviewed papers that say that levothyroxin works just as well if you take it at bedtime! So guess what I plan to do from tomorrow (I had to take eyedrops today - had a cataract removed last week - so didn't bother changing it for today)! So I can go back to waking at 07:00, taking the semaglutide then, and waiting the usual half an hour for my cup of tea!

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That's really good ! Can you let me know if you feel any difference taking it at night please it would be so much easier doing it that way x

klr said:

That's really good ! Can you let me know if you feel any difference taking it at night please it would be so much easier doing it that way x

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They do say that it ought to be taken at least 2 hours after eating, so if you're in the habit of a bedtime snack (I very seldom have one), it might not work. I'm on such a tiny dose, though, that I can't see it makes much difference - and one friend, who didn't know about the 30-minute restriction, was in the habit of taking hers with her morning coffee, and her doctors don't seem to have noticed...

Morning, I am having the usual side effects and trying to manage them but wondered if anyone else is struggling with sleep issues. I am going to bed between 10.30and 11pm usually and can get to sleep. However, I am waking up between 3 and 4 am most nights and really struggle to go back to sleep. I don’t eat after 7pm and wonder if it is anything to do with low blood sugars overnight now I am on the trial drug. I also take metformin and jardience. I don’t have a tester for checking as diabetic nurse felt it was not needed.