Hi Molly. I was on max dose Metformin, Gliclazide and Sitagliptin for years with no effect which in retrospect was due to the fact that my pancreas had 'failed' and I was not a T2 but a LADA. I'm now on insulin which works like a dream. Hopefully the Glic does work and your husband will need to be careful to avoid hypos. If the Glic works it indicates that the pancreas still has working islet cells that can be stimulated. I hope your husband does realise that he must do the right things and reduce all his carbs and not just sugar. Be aware that insulin is not the cure-all for diabetes resulting from being overweight. Weight reduction is the only real solution before adding other meds such as insulin. If necessary there are other injectables that might be better such as Bydureon.