From what I understand Metformin works by building up in your system and has no effect directly on post meal levels, you only take it with a meal to mitigate stomach upset...
I take both mine with my lunch, I used to have stomach problems with them but pretty good now, I can even take them with no food in a pinch....
So would say if you have stomach probs take them as far apart as you can (with food),... so you can deal with them one at a time...
But when I had problems with them to begin with I liked to get then all down before 6pm , simply because if my stomach played up I wanted to be able to rush to the loo, could be nasty if you were asleep

if you get my drift
