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BYETTA

Discussion in 'Incretin Mimetics' started by Dennis, Aug 22, 2007.

  1. cugila

    cugila · Master

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    Re: Anyone use Byetta?

    Have you lost weight at all ? I would also be interested to know what sort of amount of carbs you were eating at that main meal. What did it consist of ?
     
  2. Trulee

    Trulee Type 2 · Well-Known Member

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    Re: Anyone use Byetta?

    Over the two and a half months I've been on Byetta have lost just about a stone altogether.

    That last meal was not a great one, burgers, oven chips and baked beans, but am not trying to 'low carb' at the minute - am just so frustrated :?
     
  3. cugila

    cugila · Master

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    Re: Anyone use Byetta?

    Hi Trulee.

    Personally I would put this down to the combination of weight loss which will decrease your own Insulin resistance and the excessive use of Gliclazide. Do not despair it will all get sorted I am sure.
     
  4. Trulee

    Trulee Type 2 · Well-Known Member

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    Re: Anyone use Byetta?

    Thank you - I know it will eventually.

    The frustration is that we go from the meds not working to them working too well and there appears to be no happy medium :roll:
     
  5. oracle33

    oracle33 · Member

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    Re: Anyone use Byetta?

    Hi all,

    Been a while since I have posted. Ive been on the spit since May and have lost 3 1/2 stone since then and until last month bloods were doing well, sticking between 5 and 6 through the day.

    I always start a pen on the 1st of the month so I dont get confused and this month has been terrible. My bloods have shot up to 15 and 16 even overnight. I put it down to a reaction to the flu jab, and got a poke from the candida stick fodue to my high blood levels. Yesterday while I was injecting I noticed there was over half the pen left - after 25 days. So Ive not been getting the full spit dose. Phoned my nurse who replaced the pen straight away - and today Im back down to bloods of 7. I should have noticed sooner and am kicking myself for not realising, but at least its sorted now. Im sure this is very rare , but just wanted to share.
     
  6. Sillymilly

    Sillymilly · Member

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    Re: Anyone use Byetta?

    Hi Guys,

    I am nearing the end of my third month on Byetta.

    In the first 5 weeks I lost just over a stone in weight but now I seem have stayed the same, well less a couple of pounds. Have to say when I started the 10 I was really struggling with the sickness feeling. I couldnt manage to leave it an hour before eating and had to eat after 30mins. I now can leave it longer without feeling so sick thank goodness. I am gutted that I am just not loosing much weight now. Coming to the end of the third month and feeling a bit disheartened.

    Dont know if this is a coincidence or not........but has anyone had problems with heart palpitations/irregular heart rythum whilst on the Byetta. It may not be that, Im pretty sure it isnt but just wondered. The past two weeks I have had serious problems with it, which is getting worse and had to have an emergency appt with my GP who has now referred my to a cardioligist this week. I have also had my Swine Flu which was two weeks ago so MAYBE its related, dont really know.

    Would love to know if anyone else has had a problems.

    Thanks for listening
     
  7. cugila

    cugila · Master

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    Re: Anyone use Byetta?


    First of all congratulations on the weight loss. Sometimes it does stall, but if you stick to your diet or even tweak it a little I am sure it will start again. Just be patient and it will move with a little help.

    Byetta is supposed to be taken within the hour leading up to a meal, you dont have to inject and wait an hour. I frequently inject and eat a few minutes later. Others find it is better to wait 15 - 30 mins. See how it affects you with different timings.

    There is no recorded known side effect such as you describe regarding heart palpitataions etc listed at the Emea (European Medicines Agency) or in the BNf (British National Formulary).

    However this was reported on another website:
    39,694 reports are studied for females and males at all ages when using Byetta:
    Comparison with the patient's adverse outcomes:
    Name Count (% of total reports)
    Tachycardia 45 (0.11%) So it might be but these reports have not been verified as yet.

    Could be down to stress if you are worrying about the lack of weight loss ? It is best you see the Cardiologist and let them do a proper investigation. Let us know how you get on.
     
  8. FordPrefect

    FordPrefect · Well-Known Member

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    Re: Anyone use Byetta?

    Just a quick update. Seven weeks and early drop in blood sugar levels seems to have subsided and am now creeping back up to my original levels, have also lost a minimal amount of weight, still on the 5 microgram dose though at the moment. I seem to have wildly erratic blood sugar levels tho ranging from below 4 to about 10.5 which admitedly is a better than the 13/14 spikes after meals I was getting.
     
  9. gppixelworks

    gppixelworks · Member

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    Re: Anyone use Byetta?

    Firstly, many thanks to everyone who has posted their experiences on this tread. I've read through the entire thread during my research to lower my Bg.

    I am type 2 diagnosed in 1996 in Southern California. Consider myself extremely fortunate to have a friend who strongly recommended that I see a top endocrinologist at a place called Scripts in San Diego as my (American) GP was not adequately addressing the problem. I immigrated to England with my wife (who was born here) in 2006. (For those who ask, "Why?," I can tell you that, overall, life is far better in England than America. Really.)

    My diabetes medication for the last 5-6 years:

    Metformin 1,000mg 2x daily
    Glibenclamide 5mg 3x daily (2x AM; 1x PM)

    The last two years I've had a very difficult time controling Bg. Waking up is the worst with a range from 10.0 to 12.7 or so. It doesn't seem to matter what bedtime numbers are. I can go to bed with 4.4 or 7.0 and still wake up with 10-12.7. Some days the Bg would come down within a couple hours. Other times it wouldn't get below 7.0 until mid afternoon (I'd even have eaten the same food in both cases). Depressing, really.

    BMI 29.5

    HbA1c's over the last two years:

    6.7% Dec 2006
    8.6% Nov 2007
    9.1% July 2008
    8.4% Nov 2009

    I spent several days researching what the next step should be as, until this month, the "diabetic clinic" (in name only as there are no professional qualifications in diabetes or endocrinology) at the local surgery provided no meaningful guidance to get my numbers to a safe level. Comments such as, "it could be just a blip in your HbA1c's," is one, unhelpful, example of the feedback.

    Thus, I started researching insulin on my own to learn more as, based on my experience, those at the surgery didn't initiate a treatment regime even after the 9.1 HbA1c result. During this research to find the best insulin treatment for myself I came across Byetta and Victoza and some oral medications (which I quickly discounted).

    After studying the various papers, I felt Byetta would be the best in my case. I liked that it worked in a different way to my current medication, i could add it to my current medications (perhaps at a lower dose of Glibenclamide). The medical profession always drives home how important weight loss is and that seemed a far better possibility than a weight gain with insulin.

    There seemed to be a large percentage of patients with GI side effects. Still, it seemed worth a go. Even more so that in the past I very rarely experience side effects from medication. (Fingers crossed.)

    At the "diabetic clinic" a few weeks ago, I advised the nurse that I wanted to start on Byetta. She smiled. She had to talk to the doctor that deals with diabetes at this surgery and someone would get back to me.

    After a day and a half with no word I emailed the surgery inquiring about the status. The doctor advised (rather strongly, I felt) against Byetta. He said I should be on insulin and that was his recommendation and to come in and talk to him.

    I was upset. I'd read the latest NICE guidelines (#87). I'd read the clinical papers and summaries on Byetta. I'd read all of your experiences in this thread. I checked public reports from my PCT which proudly stated the "Quality Prescription" level they feel they've achieved and the fact their PCT's prescription costs 6% below the national average.

    I was ready to battle it out with the doctor this morning during our consultation.

    Listened to all he had to say; I didn't say a word until he was done. Did find some of what he stated was not quite 100% accurate. For example (paraphrasing):

    Byetta will only work for about a year at which point you will have to go on insulin anyway; so you might as well get started on insulin now.

    We can only expect to get a 1 point drop in your HbA1c (from 8.4% to 7.4%) so it's not enough of a reduction on Byetta anyway.

    A problem with Byetta is there are only a couple dosage levels. You start and the maximum you can go up to is '10.' But with insulin there is no upper limit. [Note, he got the dosage and time-frame wrong. I politely corrected him.]

    While I would quite likely been able to hold my own based solely on the papers I'd read (including, oddly enough, the NICE guidelines) it was the wealth of information all of you provided in this forum that helped give me the confidence to go and firmly tell this doctor (not my regular doctor) I feel Byetta is a superior choice to get my Bb back to a safe level.

    The doctor agreed to put me on Byetta stating that I made my case. I think his justification for prescribing Byetta was my bringing up weight and BMI. At the end he said that Byetta could be prescribed in cases where weight is a concern. If that is all he needs to justify prescribing Byetta, I'm not going to argue.

    After that was settled, he inquired as to how often I tested. I told him it varried based on what I ate, my activety level, state of health and if I felt a hypo or not. Then figured it was, perhaps, 2 to 3 times a day. Some days I don't test at all.

    His response was "That's too much. You only need to test that many times a week." I put on my "oh, that's a surprise" look and then identified the root of his comment: expense. I'd read of the push to not offer home testing to Type 2 diabetics claiming that HbA1c tests are all that is needed. When first diagnosed my American GP never mentioned home testing. I had no idea of the effect food or exercise had on my Bg. When I switched seeing an endocrinologist, I realised I was mucking about in the dark without home testing.

    So I shall start on Byetta once (I assume) he consults with an endocrinologist and gets one of the practising nurses trained in administering Byetta. I've already read the instruction online and view the online demo a couple times. Will review it again before my appointment with the nurse as my level of confidence in their experience is low.

    To hear what all of you have experience -- regardless if the experience was positive or not -- was a tremendous help. Thank you ... all of you.

    I shall post my Byetta experiences here in the hope of adding to the information already available ... hopefully shorter posts in the future. :oops:
     
  10. cugila

    cugila · Master

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    Re: Anyone use Byetta?

    Hi gppixelworks.

    Great to see somebody standing up to the medics and arguing their case....well done. Hope it all goes well for you. Made good reading as far as I'm concerned. :D
     
  11. Patch

    Patch Type 2 · Well-Known Member

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    Re: Anyone use Byetta?

    I did the exact same thing with my GP - I'm now on the waiting list for a hospital appointment to start treatment with Byetta. As long as you go in there armed with as much info as you can get your hands on, you should be okay. They prey on your ignorance - so if you're armed to the teeth with info, they can't do that.

    Treating Type 2's with insulin is ridiculous.

    when I see the specialist at the hospital, I'll be asking about Victosa as well as Byetta.
     
  12. thedame

    thedame · Member

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    Re: Anyone use Byetta?

    Hi gppixelworks :D

    Thankyou for you very comprehensive post - you certainly did your research. You experience sadly highlights the patchy quality of care for Type 2 diabetes in this country. Only yesterday I was having a discussion in another forum (not a diabetes forum) with other Type 2's, many of whom had not been offered home testing facilities - this is crazy! I agree that once settled into your treatment, cutting down the testing might be a good idea- it can be liberating not have to do it every day. However, as I have seen myself with an elderly friend, a lack of testing can lead to all sorts of complications meaning more of a drain on our already strained NHS resources with extra appointments, testings and consultations - and that doesn't even address the psychological affect on people suffering a set back.

    I wish you best of luck on your Byetta journey and look forward to hearing about it -as will others on here, I am sure.

    Before I go (and I will report back on my own progress after I see my nurse next week) I just wanted to add a comment following a discussion a few pages back on the subject of small bubbles in the pen. I had this problem and after various advice and chats, I discovered that the problem was that the lounge where I was storing the currently used pen (new ones into the fridge, please!) was too warm once the central heating kicked in. Now the pen is back in it's previous home in the cool, tiled downstairs cloakroom, the tiny bubbles have gone leaving just the usual solitary one. Also, around the time of the bubbles, I was getting bruising on the injection sites- that has gone too! HTH :D
     
  13. cavanagh1

    cavanagh1 · Newbie

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    Re: Anyone use Byetta?

    I have just started using Byetta last week and I am quite pleased with the results so far. I am eating smaller portions and find I dont want to eat between meals. My glucose level has come down from 14 to 11-9 and the sickness I had for the first few days has gone away. I am flying to New York in a few days to board a cruise round the Carabeen for christmas and new year and I am due to go up to 10ml on Christmas Day so will see how I go on. The only problem being I wont be taking advantage of all that lovely food as Byetta just dosnt let me have it. I love food and I think it is quite amusing that I now get half way through a meal and give up as I am full My partner is astonished as he says I was never full and was alway eating. Will post again when I get back in the New Year Happy Christmas everyone :eek: :D
     
  14. RWJ

    RWJ · Active Member

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    Re: Anyone use Byetta?

    Hiya

    Just an update on my fist month on Byetta. Went for check up today and my blood pressure is down and I have lost 10lb in weight. I am so happy. I am starting the higher dose of 10 on Thursday as I have been well on the 5 with no real sickness at all, just a couple of sickly mornings but nothing drastic.

    I just hope the sickly feelings don't worsen just because it is a higher dose, but I will be prepared just in case.

    Good luck to anyone who is starting on Byetta. This is the fist time I have ever not felt like eating between meals and eating much smaller portions and not really even thinking about food.

    Will let you know how I get on with my first week on 10.

    RWJ :D
     
  15. Jimbeau

    Jimbeau · Newbie

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    Re: Anyone use Byetta?

    Have been on the 10ml does for just over a week now and no real negative responses. Control is very good in the main with odd spikes for no apparent reason late in the afternoon.

    I was obliged to phone the hospital and ask about the weight loss, I was mildly alarmed at the rate it was being lost. The reply was "No worries". In five weeks I have lost over 10lbs.

    I continue to over estimate how much I need to eat at each meal and end up leaving some.

    The mean reading is 7.
     
  16. RWJ

    RWJ · Active Member

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    Re: Anyone use Byetta?

    Hiya

    Picked up my second pen today, so will be starting on 10 tomorrow.

    Just a quick question, when you take your pen out of the fridge, can you use it straightaway or do I have to wait a while, can't remember what I did with my first one.

    Thanks.
     
  17. cugila

    cugila · Master

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    Re: Anyone use Byetta?

    Jimbeau.
    Glad to hear you are doing well on the Byetta. The afternoon spikes may be related to either the type of food you ate or the amount of carbohydrates consumed, all have a knock on effect.

    I am in agreement with the Hospital over the weight loss. An average of 2lbs per week is pretty good and certainly not a problem. I suppose it does depend on what, if any, weight you may be aiming to lose.

    Byetta is a very good appetite suppressant, so much so, that I ended up eating my main meals off a side plate. Great way to control portion sizes.

    As for your mean reading of 7 I presume that is the daily figure. Do you know what your readings are two hours after meals ?
     
  18. cugila

    cugila · Master

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    Re: Anyone use Byetta?

    When you first take a pen out of the Fridge you should leave it at room temperature for around an hour before using. After that make sure it never goes above 25 deg C otherwise it destroys the Byetta. Don't leave it anywhere near Central Heating Rad's or windows, just a cool place.
     
  19. RWJ

    RWJ · Active Member

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    Re: Anyone use Byetta?

    Hiya

    Well, just getting to the end of my second day on Byetta 10. I am feeling a little sicky but more tired than anything. I have just got out of bed from an afternoon rest. Its a good job I only work part time or I would have been asleep at my desk!

    Did changing to 10 make anyone else tired?

    Other than that feel great - just not hungry. I know I should be taking it now to have something to eat but I just do not feel like eating.

    Will leave it half an hour and then will try to eat something.

    Hopefully this feeling should pass over the weekend.

    I just keep thinking of the weight loss.

    RWJ
     
  20. Iain77

    Iain77 · Member

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    Re: Anyone use Byetta?

    Hello,

    I started the 10mg pen on Tuesday 1st Dec.
    I have been fine ......Just once i felt a bit queezy and didnt want to eat,This morning my blood sugar reading was at 12.4 but dropped again to 6.1 before lunch,My usual readings now on byetta are between 5.7 and 6.1 a big change from between 7.7 and 8.9.

    I have an appointment with my diabetic nurse in a fortnight ,I am happy with the way things are going.

    What i want to ask is
    Has anyone experienced burning when injecting Byetta?
    I dont get the burning all the time and it only lasts for seconds but is very uncomfortable.

    Iain
     
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