Cognitive Impairment

[Alineden]

Hi. Do any of you know if there is any link between type 2 diabetes and cognitive impairment/dysfunction. I understand that there are many causes of cognitive impairment but wondered if diabetes can also be a cause.

 

[Guzzler]

In my opinion there is a definite link. Some people report 'Brain fog' as a symptom of Insulin Resistant Diabetes and some report a lessening or disappearance of these symptoms as bg levels and insulin resistance improves.
Alzeimers Disease is now sometimes referred to as Type 3 Diabetes. Amy Berger is now researching Alzeimers and her recent guest spot on Ivor Cummins podcast series is fascinating listening.

About an hour.

 

[Alineden]

In my opinion there is a definite link. Some people report 'Brain fog' as a symptom of Insulin Resistant Diabetes and some report a lessening or disappearance of these symptoms as bg levels and insulin resistance improves.
Alzeimers Disease is now sometimes referred to as Type 3 Diabetes. Amy Berger is now researching Alzeimers and her recent guest spot on Ivor Cummins podcast series is fascinating listening.

About an hour.

Thanks Guzzler. I'm at work now but will put it on later.

 

[pixie1]

Brain fog is normally through carb diet. Many people have mentioned this. This is what I found years and years before i developed diabetes. When i went on a low carb high fat diet my mind became so much sharper, which was great when I did my courses.
T3 diabetes referred to those who developed diabetes in another method from T1/2.
They still do not know how alzeimers develop. I have lost count the theories. I have worked for 25 years in dementia care and not seen any evidence diabetes causing dementia. Or the other way round

 

[Guzzler]

Brain fog is normally through carb diet. Many people have mentioned this. This is what I found years and years before i developed diabetes. When i went on a low carb high fat diet my mind became so much sharper, which was great when I did my courses.
T3 diabetes referred to those who developed diabetes in another method from T1/2.
They still do not know how alzeimers develop. I have lost count the theories. I have worked for 25 years in dementia care and not seen any evidence diabetes causing dementia. Or the other way round

Berger is researching the link between insulin resistance, hyperinsulinaemia and Alzheimer's.

 

[Brunneria]

Berger is researching the link between insulin resistance, hyperinsulinaemia and Alzheimer's.

Yes, and the stats suggest a strong link. The incidence of Alzheimers in T2 patients is significantly higher than in the general population.
https://www.diabetes.co.uk/conditions/alzheimers-and-diabetes.html

Although, of course, there are other forms of cognitive impairment than just Alzheimers! And I am afraid that I do not have any information on whether there are links between them.

 

[Guzzler]

Yes, and the stats suggest a strong link. The incidence of Alzheimers in T2 patients is significantly higher than in the general population.
https://www.diabetes.co.uk/conditions/alzheimers-and-diabetes.html

Although, of course, there are other forms of cognitive impairment than just Alzheimers! And I am afraid that I do not have any information on whether there are links between them.

I found the the segment on the video discussing Amyloid plaques particularly fascinating and Berger's hypothesis on these deserve further research. Of course, as you say, there are different types of dementia and no doubt some may prove to have slightly different causes.

 

[pixie1]

I have worked with people with Alziemeres for 25 years, in many different settings. I have not seen any evidence at all to suggest insulin resistance causes Alzheimer's.
It is one of many hpothese I have come across, for various causes over the years.
Plus in those 25 years I have found very few people with T2 diabetes.
I can safely say if the hyothese was correct, I would be looking after a lot more people with diabetes who have Alzheimers than I do.

In fact, the group's of people I have cared for in hospital settings with T2 diabetes are the ones with diabetic complications have been significant.

 

[pixie1]

Yes, and the stats suggest a strong link. The incidence of Alzheimers in T2 patients is significantly higher than in the general population.
https://www.diabetes.co.uk/conditions/alzheimers-and-diabetes.html

Although, of course, there are other forms of cognitive impairment than just Alzheimers! And I am afraid that I do not have any information on whether there are links between them.

I have just read through the link given. I didn't read anything to suggest there is a link.
It's all hypothetical. They so not know the cause. All they done is play snap, placing symptoms side by side. There are many conditions which have similar symptoms which mimic each other but not related.

Simple dehydration can cause exact same symptoms described in the link. Many medications also play a role..

 

[lucylocket61]

I only have my personal anecdata to share. I have ME?CFS and my brain has sharpened up considerably since going lowish carb (although some of my family members may dispute that lol)

 

[kokhongw]

Hi. Do any of you know if there is any link between type 2 diabetes and cognitive impairment/dysfunction. I understand that there are many causes of cognitive impairment but wondered if diabetes can also be a cause.

Cognitive impairment begins with reduced glucose uptake in our brain cells...
You may find Dr Stephen Cunnane's recent presentation rather insightful...

 

[kokhongw]

This paper provides a pretty good review of the issues, although it didn't discuss how FGF1 might make a difference...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277874/

 

[Tophat1900]

It is one of many hpothese I have come across, for various causes over the years.
Plus in those 25 years I have found very few people with T2 diabetes.
I can safely say if the hyothese was correct, I would be looking after a lot more people with diabetes who have Alzheimers than I do.
.

Given the number of people out there who are T2 that are simply undiagnosed and have no idea they are living with the condition or have hyperinsulemia, but not yet diabetic. I don't feel the hypothesis can be simply written off that easy. I'll remain open minded (Not saying you're not) to ongoing research.

 

[kokhongw]

Cognitive impairment begins with reduced glucose uptake in our brain cells...
You may find Dr Stephen Cunnane's recent presentation rather insightful...

This is the general concept discussed with supporting brain imaging for glucose/ketones uptake etc...

 

[kokhongw]

The brain energy gaps as noted in his studies , there is close to 20% energy gap, especially glucose uptake, in non-treated AD group.