My brother-in-law who is diabetic got a small sore on the sole of his foot. It wouldn't heal and he was in so much pain that 3 times we took him to A&E. Unbelievably, they never even looked at it on 2 occasions. Just sent him home with pain killers. It wasn't til he had a podiatry appointment that they suddenly decided to hospitalise him. By this time he was suffering with septicaemia. He spent over a year in hospital having toes amputated one by one and all the debridement treatments (they even put maggots in a cage over his wound) but it was no use and his leg got redder and more infected further up until he finally opted for amputation. They took his leg off above the knee and he was so weak he couldn't get on with the prosthetic leg.
To cut a long story short, after a fall at home where he broke the hip on his good leg side he is now in a very bad way