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Confused by Dr Mason's presentation
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<blockquote data-quote="Colin of Kent" data-source="post: 2163657" data-attributes="member: 468270"><p>In this video (<a href="https://l.facebook.com/l.php?u=https%3A%2F%2Fyoutu.be%2FTRB0jOfymLk%3Ffbclid%3DIwAR2Xoq1dpRXhCZovzlaFDiM8nOzT3LRFFldAwUQhQiXAuw1qmhL4yCrV1EA&h=AT3sN4TVDHx2Ln9rlD7dewPOFrrTmfhC1IfbV6XWwOSP1GWpIKPKNJ5yTI12KcB5XV23iMsD9VP73DtB27L1skIieL8dkLJipoJfJhby0usIBnZ6cr6alSuCdVuVgdaVDsR9CEQkBHX4_AdggI-zhZHT7L3MEz47LIXFMIHREHzQ5gQKBjefz0s" target="_blank">https://youtu.be/TRB0jOfymLk</a>), Dr Paul Mason says that by reducing the number of pattern-A LDL particles, the ratio between pattern A and pattern B is made worse, and that this is associated with worse cardiovascular outcomes. To check this out, I looked up the paper referenced in his slideshow: <a href="https://doi.org/10.1161/01.CIR.0000141728.23033.B5?fbclid=IwAR2TlOJBlfmkJKthpbWNwWtvdZuu_qdgaA_TZLdmsdJw6OsWoBd9GigskKQ" target="_blank">https://doi.org/10.1161/01.CIR.0000141728.23033.B5</a> -- But this seems to indicate that taking 80mg Atorvastatin results in improved clearance of OxPL, which "may contribute to a reduction in ischemic events after ACS." </p><p></p><p>Where does he get the idea of an association with worse CV outcomes? Did I miss something? Am I looking at the right paper?</p></blockquote><p></p>
[QUOTE="Colin of Kent, post: 2163657, member: 468270"] In this video ([URL='https://l.facebook.com/l.php?u=https%3A%2F%2Fyoutu.be%2FTRB0jOfymLk%3Ffbclid%3DIwAR2Xoq1dpRXhCZovzlaFDiM8nOzT3LRFFldAwUQhQiXAuw1qmhL4yCrV1EA&h=AT3sN4TVDHx2Ln9rlD7dewPOFrrTmfhC1IfbV6XWwOSP1GWpIKPKNJ5yTI12KcB5XV23iMsD9VP73DtB27L1skIieL8dkLJipoJfJhby0usIBnZ6cr6alSuCdVuVgdaVDsR9CEQkBHX4_AdggI-zhZHT7L3MEz47LIXFMIHREHzQ5gQKBjefz0s']https://youtu.be/TRB0jOfymLk[/URL]), Dr Paul Mason says that by reducing the number of pattern-A LDL particles, the ratio between pattern A and pattern B is made worse, and that this is associated with worse cardiovascular outcomes. To check this out, I looked up the paper referenced in his slideshow: [URL='https://doi.org/10.1161/01.CIR.0000141728.23033.B5?fbclid=IwAR2TlOJBlfmkJKthpbWNwWtvdZuu_qdgaA_TZLdmsdJw6OsWoBd9GigskKQ']https://doi.org/10.1161/01.CIR.0000141728.23033.B5[/URL] -- But this seems to indicate that taking 80mg Atorvastatin results in improved clearance of OxPL, which "may contribute to a reduction in ischemic events after ACS." Where does he get the idea of an association with worse CV outcomes? Did I miss something? Am I looking at the right paper? [/QUOTE]
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