Confused by Dr Mason's presentation

Colin of Kent

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In this video (https://youtu.be/TRB0jOfymLk), Dr Paul Mason says that by reducing the number of pattern-A LDL particles, the ratio between pattern A and pattern B is made worse, and that this is associated with worse cardiovascular outcomes. To check this out, I looked up the paper referenced in his slideshow: https://doi.org/10.1161/01.CIR.0000141728.23033.B5 -- But this seems to indicate that taking 80mg Atorvastatin results in improved clearance of OxPL, which "may contribute to a reduction in ischemic events after ACS."

Where does he get the idea of an association with worse CV outcomes? Did I miss something? Am I looking at the right paper?
 

ianf0ster

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In this video (https://youtu.be/TRB0jOfymLk), Dr Paul Mason says that by reducing the number of pattern-A LDL particles, the ratio between pattern A and pattern B is made worse, and that this is associated with worse cardiovascular outcomes. To check this out, I looked up the paper referenced in his slideshow: https://doi.org/10.1161/01.CIR.0000141728.23033.B5 -- But this seems to indicate that taking 80mg Atorvastatin results in improved clearance of OxPL, which "may contribute to a reduction in ischemic events after ACS."

Where does he get the idea of an association with worse CV outcomes? Did I miss something? Am I looking at the right paper?

Please post if/when you get an answer, because I too am rather confused by this - as I'm sure are lots of others.

For me the big question is can I trust
A). the study conclusion? - I have seen many where the actual results contradict the conclusion.
B). the study environment set-up?

It is terrible that it is so hard to find studies which are reasonably independent, rather than those funded by vested interests.
And how many studies funded by vested interests are published with a conclusion against the vested interest? - Almost none !
 
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