There were several outbreaks of the sweating sickness between 1485 and the final epidemic in I believe 1551 no one knows even now what it actually was.
the disease would begin suddenly with a sense of apprehension, followed by violent cold shivers, giddiness, headache, exhaustion and severe pains in the neck, shoulders and limbs. After sometimes as little as half an hour, profuse sweating broke out suddenly, accompanied by a sense of heat, headache, delirium, rapid pulse and intense thirst. In the final stage, sufferers experienced a heaviness and a desire to sleep. After 24 hours they were either dead or recovering.