Good info.
Dan, did you get a lot of night-time sugar highs from periodically spiking those carbs? Or was your high insulin sensitivity enough to keep insulin requirements reasonable.
From my personal experience, I can tolerate more carbs only on the same day
after I do vigorous exercise. Of course nowhere near as vigorous as yours.
I also wanted to ask, for those of us who simply do not have enough spare time to run that many hours a week, do you think running faster for less distance would be effective?
Or is it really about the distance travelled (or duration). For instance, what do you think about running one hour, really fast, every day, on the treadmill, and trying to maintain a catabolic state as long as possible through periodic intermittent fasting to prolong the stress period of the run. I often feel like I'm floating on a cloud for hours after a good run, but if I don't eat more than an hour after I start getting the shakes, no matter what I do I become a mess. Must be my insulin on board, surely.
If I can follow in your footsteps (no pun intended) but using a more reasonable / moderate training regimen, that might help more people do it. I have very low antibody levels and other tricks up my sleeve to reduce auto-immunity (pills, foods, etc) so I'm more concerned with trying to replicate your "reboot" of the signalling and beta cell numbers and proper functioning.
My latest CP was 0.051 nmol / L, which is down from 0.11 nmol / L last year before I stopped taking GLP-1 (no insurance to pay for it). I just got some samples of Ozempic that'll last a few months so I'm fairly sure my next CP test will be higher again. The highest I ever got was 0.17 nmol / L using a combination of drugs, with 0.26 nmol/l the low end of normal range (one could get by with such numbers with zero external insulin, presumably, if eating low carb and having high insulin sensitivity). So, to anyone out there who thinks it's impossible to significantly alter their own beta cell function: that's provably false. The easiest way is taking GLP-1 meds, and with that you can see the results right away.
I'm following your supplements listed, plus GABA 750mg twice a day, (any more than that and it feels awful). Still haven't added glycine yet, since GABA + glycine are apparently required for natural GLP-1 production which is implicated in
glucose-mediated insulin release in the pancreas, which in turn releases serotonin which puts on the breaks on alpha cells releasing glucagon at the same time (no use pushing the gas and the breaks at the same time, to make an analogy). I'd much rather stimulate natural GABA production than take it in a pill, and of course GLP-1 meds are super expensive. All natural is best (diet + exercise) but I know for sure that certain meds help too. And by that I mean, meds other than insulin, to reduce insulin requirements. Of course the easiest way to reduce your insulin needs is simply the tried and true method of low carbing and intense exercise, as you've done, so I congratulate you again! Most of us are going to need a bit more help I think than some zinc + other multi-vitamins. But I'm convinced those are probably necessary too.