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Dapagliflozin

C

CarolFrancis2018

Newbie
Messages
3
Type of diabetes
Type 1
Treatment type
Insulin
I am a long standing diabetic 1 with heart, kidney, eye, sleep apnoea, skin problems and pulmonary hypertension!!!. Are there any Diabetic 1s using dapaglifloxin? My renal consultant would like me to try it. I have read up quite a lot but really not sure whether or not to give it a trial, only 5mg, but diabetes nurse wants me to reduce my insulin before I start and I only have to look at food before my sugar rises and not to take it if unwell. Any comments would be much appreciated. Carol Francis
 
Hi @CarolFrancis2018 and welcome to the forums.

I'm not on it myself and as far as I know it's more commonly used for T2s. But if you've got insulin resistance
CarolFrancis2018 said:
I only have to look at food before my sugar rises
Click to expand...
then I'm guessing that that might be why they think you are a good candidate (aside from the obvious fact that it's recommended to help with heart and kidney issues).

As regards reducing the insulin, I'm guessing she reckons it will reduce your blood sugars and so wants you to start on a lower dose, which presumably you can then increase if you find it isn't enough?

The only specific T1 downside I can see from the description is that you'll need to watch out for DKAs, which is probably why she's told you to stop taking it if you are ill.

Would you like me to change the title of your thread so that it reads dapaglifloxin instead of dapa?
 
EllieM said:
Hi @CarolFrancis2018 and welcome to the forums.

I'm not on it myself and as far as I know it's more commonly used for T2s. But if you've got insulin resistance

then I'm guessing that that might be why they think you are a good candidate (aside from the obvious fact that it's recommended to help with heart and kidney issues).

As regards reducing the insulin, I'm guessing she reckons it will reduce your blood sugars and so wants you to start on a lower dose, which presumably you can then increase if you find it isn't enough?

The only specific T1 downside I can see from the description is that you'll need to watch out for DKAs, which is probably why she's told you to stop taking it if you are ill.

Would you like me to change the title of your thread so that it reads dapaglifloxin instead of dapa?
Click to expand...
 
Yes please to change to dapaglifloxin, just a difficult word to type!! Thank you for your reply. It would be good to hear from someone who is a Diabetic 1 and takes it.
 
CarolFrancis2018 said:
Yes please to change to dapaglifloxin, just a difficult word to type!! Thank you for your reply. It would be good to hear from someone who is a Diabetic 1 and takes it.
Click to expand...

Hopefully someone will post but a forum thread search on the T1 forum only gave me one member who was taking it, and they haven't been online for two years. I'll keep my fingers crossed for you.

(And I edited the title as requested)
 
hi Carol
Are ;you in the UK? I thought this type of drug (sglt2 inhibitor that makes yu pee out some of the glucose) was not normally on the cards for a type 1? See this advice Dec 21 noting that there are no immediate safety concerns but maybe something to discuss with the team as the guidance I lifted from a gov website isn't very illuminating!
Advice for healthcare professionals:
  • dapagliflozin 5 mg is no longer authorised for the treatment of patients with type 1 diabetes mellitus
  • the removal of the type 1 diabetes indication is not due to any new safety concerns and the other indications of dapagliflozin are unchanged
  • dapagliflozin should be reviewed and discontinued in patients with type 1 diabetes by or in consultation with a physician specialised in diabetes care as soon as clinically practical
  • after stopping dapagliflozin treatment, frequent blood glucose monitoring is recommended
  • an increased insulin dose may be needed, which should be undertaken carefully to minimise the risk of hypoglycaemia or hyperglycaemia
  • diabetic ketoacidosis is a known risk with use of dapagliflozin in all patients with diabetes, but it occurs more frequently in patients with type 1 diabetes than those with type 2 diabetes
  • additional risk minimisation materials to mitigate the risks in patients with type 1 diabetes are no longer available
  • report suspected adverse drug reactions associated with use of dapagliflozin on a Yellow Card
 
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