Diabetes & kidney problems

[IanD]

At the recent Hounslow support group, Dr Chatterjee spoke of his research into renal problems related to diabetes.

Katsoulieris, Elias, Mabley, J.G., Samai, M, Green, Irene C. and Chatterjee, Prabal K. (2009) "Alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress" European Journal of Pharmacology, 623 (1-3). pp. 107-112. ISSN 0014-2999
[I couldn't access the link.]

An interesting point is that the saturated fatty acid - palmitic acid - was shown to damage kidney cells, whereas the unsat linolenic acid repaired the damage. Tests carried out feeding diabetic rats with linseed showed the improvement in live subjects.

Butter comprises:
Saturated fatty acids:
Palmitic acid: 31%
Myristic acid: 12%
Stearic acid: 11%
Lower (at most 12 carbon atoms) saturated fatty acids: 11%
pentadecanoic acid and heptadecanoic acid: traces

Unsaturated fatty acids:
Oleic acid: 24%
Palmitoleic acid: 4%
Linoleic acid: 3%
Linolenic acid: 1%

I was quietly panicking so I continued googling:
Palmitic acid: the horror never ends

Read about inflammasones in tissue culture and quake. Here is the relevant line:

"These findings provide insights into the association of inflammation, diet and T2D."

It gets even better. Here is the best line from the press release:

"These results support the idea that inflammation plays a role in chronic disease," says Ting. "The simple message is to avoid fatty foods as much as possible."

OK, you take isolated cells, bathe them in 2mmol palmitic acid and they become unhappy. This is supposed to have something to do with eating a high fat diet?????

Just for fun I'm going, in my head, to eat some (gasp, horror) palmitic acid. Please don't do this at home, you probably don't want to inflame your inflammasomes.
.......
That's it, one tenth of one millimole of oleate completely negates the adverse effects of isolated palmitate.

Panic over - spread the butter thick!

Dr Chatterjee did say he would answer further questions ....

 

[Sid Bonkers]

So eating saturated fat is like playing Russian Roulette with a loaded gun then, or am I
reading this wrong?

 

[LittleGreyCat]

No - you should treat yourself like a cricket bat and rub in Linseed Oil before and after every match.

 

[IanD]

So eating saturated fat is like playing Russian Roulette with a loaded gun then, or am I
reading this wrong?

That was the message - but only from using fats with 100% palmitic acid.

Sat fats in actual food would not appear to be the same danger, if any.

If you are not confused, you haven't understood .... :roll: :?:

See also A low-carbohydrate diet may prevent end-stage renal failure in type 2 diabetes. A case report.

I must get Dr Chatterjee to clarify.

 

[Sid Bonkers]

That was the message - but only from using fats with 100% palmitic acid.

Sat fats in actual food would not appear to be the same danger, if any.

I did mean it tongue in cheek Ian although saying one type of fatty acid will harm you but its OK as another will repair the damage still sounds like saying its OK to slash your wrist open as long as you put a couple of butterfly strips on the cut and bandage it afterwards :lol:

I think I'll stick to not overdoing it on the amount of Sat fats I eat thanks

 

[IanD]

That was the message - but only from using fats with 100% palmitic acid.

Sat fats in actual food would not appear to be the same danger, if any.

I did mean it tongue in cheek Ian although saying one type of fatty acid will harm you but its OK as another will repair the damage still sounds like saying its OK to slash your wrist open as long as you put a couple of butterfly strips on the cut and bandage it afterwards :lol:

I think I'll stick to not overdoing it on the amount of Sat fats I eat thanks

Likewise - I eat my sat fats as they come - in cheese, & relatively lean meats.