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Difference between type 2 and Lada

I'm sorry to disagree with you Lucy, but insulin resistance is one thing and diabetes T2 something else entirely. If you don't have the genes, you can be very resistant but you pancreas produces the required amount of insulin, if you have the diabetic genes you develop diabetes T2. There are people without insulin resistance with T2 too.
Type 2 are a group of poly-genetic conditions and comparably little is known, apart from some of the genes involved, that so often are shared with type 1.5/LADA.
 
Totto said:
I'm sorry to disagree with you Lucy, but insulin resistance is one thing and diabetes T2 something else entirely. If you don't have the genes, you can be very resistant but you pancreas produces the required amount of insulin, if you have the diabetic genes you develop diabetes T2. There are people without insulin resistance with T2 too.
Type 2 are a group of poly-genetic conditions and comparably little is known, apart from some of the genes involved, that so often are shared with type 1.5/LADA.
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As T1.5 and T1 are essentially the same thing but with different timescales what you are saying is that T2, T1.5 and T1 share some similar genes which many would agree with but it's not helpful? I would suggest that most T2s will have noticeable insulin resistance and that T1/T1.5 may have some but the difference between T1/T1.5 and T2 will normally be natural insulin production levels. Because quite a few T1.5s are mis-diagnosed as T2 initially doesn't mean they come from the same stable.
 
TorqPenderloin said:
I don't know if it's necessarily your GP's fault (although I understand where you're coming from). Remember that she has to know how to treat and diagnose much more than just our endocrine system. Type 1.5 may be more common than we think, but it's still very rare in comparison to many other diseases.

Here in the US, the situation isn't that much different. I was prescribed Metformin by the emergency room doctor who thought I had type 2. His job was to get me stable and release me, and I respect that. My GP's job is to find any irregularities in my health and get me to a specialist who is an expert in that part of the body.

The two biggest differences between the US and UK healthcare systems are that I can see any doctor/specialist I want and I don't need a referral. Plus, my doctors don't work for the insurance companies so there isn't a possible conflict of interest to save the system money and keep me off medication (some might argue the opposite is true).
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Hi. Yes the UK system is different from the USA one. When I lived in the USA I remember being able to select a specialist from the Yellow pages which I did when I had a kidney stone. In the UK, the system forces you to always see a GP first which can be waste of time and cost. UK GPs are also discouraged from referring patients to specialists if they can due to the cost so we often end-up being treated by well-meaning non-specialists. My GP who refused me insulin had only just come off her diabetes training course a few weeks before. She happens to be a very good GP but no one can cover such a wide range of medical subjects and deal with each in depth.
 
Daibell said:
As T1.5 and T1 are essentially the same thing but with different timescales what you are saying is that T2, T1.5 and T1 share some similar genes which many would agree with but it's not helpful? I would suggest that most T2s will have noticeable insulin resistance and that T1/T1.5 may have some but the difference between T1/T1.5 and T2 will normally be natural insulin production levels. Because quite a few T1.5s are mis-diagnosed as T2 initially doesn't mean they come from the same stable.
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No, what I'm saying is that insulin resistance doesn't cause diabetes, and that T2 and LADA share genes, while LADA also share the autoimmunity with T1, so LADA is called T 1.5 being a bit of both T1 and T2.
T2 is about the pancreas not producing enough insulin, due to higher than normal BG which is due to bad genes, not antibodies.
 
Totto said:
No, what I'm saying is that insulin resistance doesn't cause diabetes, and that T2 and LADA share genes, while LADA also share the autoimmunity with T1, so LADA is called T 1.5 being a bit of both T1 and T2.
T2 is about the pancreas not producing enough insulin, due to higher than normal BG which is due to bad genes, not antibodies.
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Well, we'll have to disagree. My understanding is that most T2s will have excess insulin production thru insulin resistance. The common cause is obesity but by no means always. The excess fat deposits from excess carb intake make the body unable to use insulin properly and the pancreas produces more in an attempt to clear the problem and meanwhile blood sugar rises. This is why the c-peptide test is part of T1.5 (or T1) diagnosis to determine low insulin levels from the higher levels in T2. Yes, 'bad' genes make all of us diabetics pre-disposed to diabetes although there are many different 'bad' genes associated with diabetes. If you are pre-disposed and gain excess weight then T2 becomes possible.
 
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