Do I need a low carb diet?

[TorqPenderloin]

It is a relatively easy fact to confirm with a bit of research.

The four studies you cited specifically note the long-term effects of Glibenclamide (Glyburide). We are specifically discussing Gliclazide in this case.

I could counter all four studies with one (or two) that specifically compares Gliclazide to Glibenclamide:
https://www.researchgate.net/public...poptosis_induced_by_intermittent_high_glucose

This study compares several different types of sulfonylureas and specifically notes glibenclamide as an outlier in comparison:
http://www.who.int/selection_medicines/committees/expert/19/applications/Sulfonylurea_18_5_A_R.pdf

I'll stick to my original statement in saying that I have yet to see any PROOF to support the theory.

 

[zand]

I have yet to see any sort of scientific proof to support this theory. It seems to be nothing more than a rumor created on one of the Internet diabetes forums.

In my post I only said '.....may wear out'....It doesn't seem logical to me to take something that can make your pancreas secrete too much insulin so that hypos are a possibility. As a diet controlled T2 I don't get hypos so I don't have to worry about them. Why make life more difficult for yourself when all you have to do is reduce carbs? If the pancreas doesn't wear out then why is T2 said to be a 'progressive disease' by the medical profession? I would prefer not to wait for scientific proof, it's often decades before such proof is available. I wasted decades following a low fat diet which was supposedly healthy. I don't have more decades to waste. I only have one life and one pancreas.

 

[TorqPenderloin]

In my post I only said '.....may wear out'....It doesn't seem logical to me to take something that can make your pancreas secrete too much insulin so that hypos are a possibility. As a diet controlled T2 I don't get hypos so I don't have to worry about them. Why make life more difficult for yourself when all you have to do is reduce carbs? If the pancreas doesn't wear out then why is T2 said to be a 'progressive disease' by the medical profession? I would prefer not to wait for scientific proof, it's often decades before such proof is available. I wasted decades following a low fat diet which was supposedly healthy. I don't have more decades to waste. I only have one life and one pancreas.

Sulfonylureas have been around since the 1950s and there are multiple generations that have evolved over time. I'm not suggesting that they're perfectly safe, but there is no conclusive evidence to prove either side of the argument. Furthermore, I have to wonder, what is the alternative?

I would tend to agree with most of your thoughts, but they require the assumption that everyone can control their T2 diabetes with diet. Obviously, it doesn't make sense to overmedicate someone, but when diet, exercise, and metformin aren't successful, what would you suggest be done instead?

The general approach is to try diet/exercise, then introduce metformin, then sulfonureas, and then insulin. Of course, there are other approaches as well, but that's the general progression of treating type 2.

 

[zand]

Sulfonylureas have been around since the 1950s and there are multiple generations that have evolved over time. I'm not suggesting that they're perfectly safe, but there is no conclusive evidence to prove either side of the argument. Furthermore, I have to wonder, what is the alternative?

I would tend to agree with most of your thoughts, but they require the assumption that everyone can control their T2 diabetes with diet. Obviously, it doesn't make sense to overmedicate someone, but when diet, exercise, and metformin aren't successful, what would you suggest be done instead?

The general approach is to try diet/exercise, then introduce metformin, then sulfonureas, and then insulin. Of course, there are other approaches as well, but that's the general progression of treating type 2.

When diet and exercise no longer works for me I will ask for metformin again. My GP won't prescribe it for me anymore as my BGs are well controlled. If that doesn't work I would prefer to go straight to insulin.

 

[TorqPenderloin]

When diet and exercise no longer works for me I will ask for metformin again. My GP won't prescribe it for me anymore as my BGs are well controlled. If that doesn't work I would prefer to go straight to insulin.

I couldn't agree more, and I chose the exact same path for myself.

Either way, my pancreas is going to call it quits. That may be in a week, a month, or a year, who knows? Some people with 1.5/LADA choose the Gliclizide route.

With type 2,there is a possibility that that process could be extended to last decade. For some people, that's worth the chance. For others (like you and me), it's a waste of time.

 

[Daibell]

When diet and exercise no longer works for me I will ask for metformin again. My GP won't prescribe it for me anymore as my BGs are well controlled. If that doesn't work I would prefer to go straight to insulin.

Hi. That assumes your GP/Doc is prepared to move you straight to insulin. Mine wouldn't move me despite an argument and being on full dose Gliclazide. Met and Sitagliptin for years. Docs will vary but there is a lot of resistance to putting you onto insulin early even though it may make sense.