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Message: <blockquote data-quote="Hoping4Cure" data-source="post: 1434580" data-attributes="member: 393050">I've discussed a few times, without any conclusions, on the other blog about whether it's best to try to reduce basal to 0 to short-acting to 0 and let basal shoulder more of the daily burden, by avoiding meals that spike sugar levels i.e. use a ketogenic diet perhaps in combination with GLP-1 and/of metformin. Who knows. I remember vaguely reading some evidence that having too much external / exogenous insulin actively hampers beta cell function and replication and endogenous insulin production. So indeed having too much injected insulin could be counterproductive.It's important for us to remember that without an appropriate / adequate source of insulin, we can go into DKA and it's important to monitor ketones to make sure they don't get too high. I remember reading about a couple type 1s in Japan died when put on GLP-1 because they stopped taking insulin when their sugars looked normal. Sugars looking normal without insulin is not necessarily a sign that injections should be stopped, is what I'm saying. It's best to be conservative here, I think. The more functional beta cells we have the more alpha - beta signalling should occur which also means not only less hypos, but less spikes because beta cells producing insulin actually tells alpha cells to put on the brakes of their own signal to the liver to release sugar into the bloodstream. So even minor amounts of increased beta cell function will have an out-sized influence on the side effects we get. That much is also borne out by some studies. Of course since beta cells are responsible for not only producing insulin but monitoring current blood sugar and in the presence of low sugar not only stop making insulin but tell alpha cells to release sugar, and so protects us from hypos. This is of course a terrific reason to try regenerating beta cells, since even minor increases in c-peptides is solid gold. As many type 1s probably have detectable c-peptides (at least with Faustman's ultra-sensitive test but perhaps even with a normal sensitivity assay), but aren't even aware of how well they're doing in this regard, I consider it irresponsible and bordering on medical malpractice to not be prescribed at least yearly c-peptide tests. It's likely that many clues that could have led to a cure were ignored or dismissed as vague happenstance, like "mini-honeymoon" when in fact something important happens in the body periodically which boosts natural insulin production and yet the old bias against the idea of a drug-free rehabilitation (even a spontaneous one) has been obvious now. Even when I showed MDs my non-zero c-peptide levels from verified labs they didn't think, "hmm, we should dig deeper" and no, it's just let's focus on diet and control, get him on a pump, boost more profits for their colleagues in the for-profit diabetes industry, which has a counter-incentive to actually curing this disease, let alone curing it naturally and in a drug-free way.</blockquote>

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