Fiasp and Varying Sensitivity

[Zinadane]

Fiasp was great for the speed, don't think much else can match it?
For me though, just lately if I'm high then it just doesn't seem to be reacting so well like I've been used to.
Just don't understand the reason for it!
You say 'train' the fiasp?

 

[Antje77]

Fiasp was great for the speed, don't think much else can match it?

There's Lyumjev, which for some is even a tiny bit quicker than Fiasp.
I''ve tried it out of curiousity and found no real difference with the Fiasp for speed, don't know about using while >10 though.

I chose to stick with Fiasp because Lyumjev stings a little, and I like my novopen w it a memory for last dose, can't use that with Lyumjev.

 

[Zinadane]

Another crazy day yesterday, where my body just would not react to the fiasp. 50g carb breakfast and took 11units before going for 9holes golf. I spent the next 8 hours battling down highs, about 8 corrective does in total 50 units! Before getting things normalised.
Absolutely crazy and mentally exhausting!
The fiasp was like water!
Only other considerations:
My wife has covid, but I have no symptoms.
I pushed myself beyond my limit previous day on bike simulator.

 

[Zinadane]

And back to normal today.
So yesterday was another one of those days where either the fiasp is not working or something else in my body is kicking the blood sugar into orbit

 

[In Response]

And back to normal today.
So yesterday was another one of those days where either the fiasp is not working or something else in my body is kicking the blood sugar into orbit

Considering the knowledge that Fiasp dose is very dependent on BG and more is needed and takes longer to work when BG is high, it looks to me as if the problem yesterday was a high BG for whatever reason

 

[Antje77]

Did you wear a different colour socks yesterday?

Glad you're back to normal!

 

[Zinadane]

Yeah, the old classic unexplained!
Probably around 90 units of fiasp yesterday compared to maybe 40 total today.
The joys!

 

[Fairygodmother]

I’m on MDI. Fiasp, which I get from a cartridge/pen/frio setup, tends to steadily lose a bit of strength for the first 1.5 ml then falls off a cliff and becomes almost useless after that.
I also agree that the amount needed increases when bs are higher.

 

[Antje77]

I’m on MDI. Fiasp, which I get from a cartridge/pen/frio setup, tends to steadily lose a bit of strength for the first 1.5 ml then falls off a cliff and becomes almost useless after that.

How long does it take for you to use up this first 1.5 ml?
I'd expect time in use has more to do with it than amount used.

I've never noticed it losing strength, but then, my penfills only last between 1 and 2 weeks.

 

[Zinadane]

I suppose my penfill will last up to 14 days as I'm split over 2 pens.
Interesting thought that it may loose potency, I wonder?

 

[Fairygodmother]

How long does it take for you to use up this first 1.5 ml?
I'd expect time in use has more to do with it than amount used.

I've never noticed it losing strength, but then, my penfills only last between 1 and 2 weeks.

It depends on what I’m eating, Antje; usually 1.5 lasts me a week.

 

[Fairygodmother]

How long does it take for you to use up this first 1.5 ml?
I'd expect time in use has more to do with it than amount used.

I've never noticed it losing strength, but then, my penfills only last between 1 and 2 weeks.

Maybe the storage and delivery systems before it reaches the pharmacy, our fridge, my Frio, need to be considered too. I know that the pharmacy keep stocks in a well-monitored fridge.

 

[Fairygodmother]

Coming back to @Zindane’s hyperglycaemia, I wonder if it’s a combination of liver dump to compensate for glucose used during intense exercise and released courtesy of stress because of wife’s Covid/prospect of also getting covid with all that implies for Type One? Maybe your immune system’s already responding, and we all know what that can do to insulin needs.
Hope your wife recovers swiftly.

Exercise Guidelines

Type 1 diabetes exercise guidelines. Some benefits of exercise include: improves blood pressure and cholesterol levels, increases insulin sensitivity and lowers blood sugar, among other benefits. UCLA Diabetes Program, Div of Endocrinology.

www.uclahealth.org

 

[Kirsssty]

I am having the exact same problems. It is like fiasp becomes unreliable once your BG is above 11 for me anyways. I wonder if there is a solution or I need a different insulin

 

[In Response]

I am having the exact same problems. It is like fiasp becomes unreliable once your BG is above 11 for me anyways. I wonder if there is a solution or I need a different insulin

The only solution I found is to avoid getting a high BG.
I think I have read about some people having another insulin to use when their BG is in double figures and Fiasp when it is lower.
I am not sure about the logistics of this such as carrying an extra insulin pen around, etc.

 

[CheeseSeaker]

I had similar issues with Fiasp - worked really well at first (3-6 weeks), then I became resistant.

I found anything above 10 and it was like injecting water (do a search on "fiasp" and "like water" and you'll turn up lots of hits).

If I injected - worked like a charm (my wife said she'd never seen me inject before (married 12 years) so that tells you how much I experimented)

I tried mixing Fiasp with Novorapid and that made it work much better - for 2-3 months, then the resistance returned.

In the end I switched to Lyumjev and experienced very similar (but not quite the same) issues, then found if I used cannula sites that were 'new' to insulin - resistance went away and it works perfectly.

Worth a go - try somewhere new on your body and see if it works

 

[Zinadane]

If my sugar gets into the mid-teens I can end up having 4 or 5 extra hits of fiasp to eventually kick it into action.
Alarming, disturbing to say the least.
Maybe, another insulin for this situation. But it gets complicated. Well even more so

 

[EllieM]

If my sugar gets into the mid-teens I can end up having 4 or 5 extra hits of fiasp to eventually kick it into action.
Alarming, disturbing to say the least.
Maybe, another insulin for this situation. But it gets complicated. Well even more so

Not clear that that is a fiasp issue? I find my insulin resistance dramatically goes up if I reach that level on humalog ... And it takes ages to get it back down.