Food combining?

SimonP78 said:

afaiu having high triglyceride levels in the blood stream does increase insulin resistance -

Click to expand...

Going down a bit of a rabbit hole, but wanted just to pick at this -
It's one of the things that is ... used as evidence ... but isn't quite correct. In a lab (and this is all Ben Bikman, he did the lab work but also the rebuttal to the way it was represented).

1 - in a lab - you can take adipose tissue cells and suffuse them in triglycerides, and show that this has an effect on the insulin receptors - which seems to indicate that fat makes fat cells insulin resistant. While this is true in a lab, the scenario just cannot happen in a human body. Triglycerides don't just float about, because they don't float - our entire lipid transport system evolved in order to chaperone fats in the form of triglycerides, and cholesterol about the body safely.

2 - in the body, it's actually the other way around - insulin resistance leads to those same adipose cells swelling up (hypertrophy) because that's what insulin does - tells those cells to take in fats and glucose and store them. Those cells swell up, causing inflammation and for triglycerides to break down into free fatty acids and leak from the cells.

In which case I'm happy to stand corrected!

I'm sure I've also read that high fat diets produce insulin resistance - or is this a similar case of mis-application of lab studies into a real-world setting?

ianf0ster said:

I don't have a reference to hand, but recently saw a Nick Norwitz video about C15 (saturated fat) which mentioned that the only evidence about saturated fat and Insulin Resistance is that Sat Fat improves (i.e. decreases) IR rather than making it worse.
Certainly, if sat Fat was making my IR worse, then how did it put me in T2D remission at the very same time?

Click to expand...

Consider me duly corrected, I shall strike "fat produces insulin resistance" from my parroting list

I agree that the UK Daily Mail is not the most reliable source of facts
and figures, and often goes for the shock headline. It's been criticised
for its unreliability; its printing of sensationalist and inaccurate scare
stories about science and medical research.

Having said that though, it's important to check out accredited medical
opinion in order to confirm or discredit what the Daily Mail often reports.

Professor François R. Jornayvaz is the Chief Medical Officer of the Department
of Endocrinology, Diabetology, Nutrition and Therapeutic Education of the
Hôpitaux universitaires de Genève. He is also an Associate Professor at the
Faculty of Medicine at the University of Geneva.

He states, of Inchauspé: "She hides behind a pseudoscientific appearance to advocate
a method which, in my opinion, doesn't work and is based on very little evidence.
The scientific studies she cites are highly anecdotal, if not outright false, or not
applicable to what she proposes".

So... do we accept the claims of the self-styled Glucose Goddess, or the research
of the highly qualified researcher professor Jornayvaz?

I'd also suggest people check out THIS site, hosted by Sophie Gastman, who holds
a First-Class BSc in Nutrition and Food Science, and is a Registered Nutritionist
(RNutr Public Health). Gastam weighs in on the science behind Inchauspé’s claims.

​

​

BoldItalic said:

I don't know the answer yet but I'm hoping to find out next month. I've been on lo-carb for a couple of years and kept my HbA1C to 41 (diagnosed at 50) but I've lost weight and my BMI dropped to around 16 which is worrying. I've been referred to a dietician who firmly believes that it's only peak glucose levels that matter and duration of peaks doesn't. She also believes in eating snacks between meals and that eating more fat and protein at the same time as carbs will reduce the effect so is urging me to eat more of everything to put on weight. I've been obediently doing that for two months now, and after another month I will get an HbA1c test done to see if it's true. I have put on about 4kg so that's working. Doing finger-prick tests, I'm getting 5 peaks a day instead of three but the peaks are indeed shorter - maybe 4 hours instead of 6 - going from a baseline of 5 to a maximum of around 8 which I can't complain about. On that basis, maybe the HbA1c won't be so bad. Fingers crossed.

Click to expand...

As a follow-up, after another 3 months, weight gain has reached 5kg, BMI is now just under 18, and HbA1c has only gone up to 45 which I'm happy about. Part of that, I think, can be attributed to the extra carbs combined with fats and proteins in the snacks but some of it, I'm sure, is attributable to the daily food supplement that I've been prescribed (it's like a fortified smoothie - essentially a meal in a bottle).

I would say, if you are naturally skinny like me, go for lo-carb to get the HbA1c down but get yourself referred to a dietician if you experience too much weight loss. Look for a happy medium.