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Food combining?

SimonP78 said:
afaiu having high triglyceride levels in the blood stream does increase insulin resistance -
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Going down a bit of a rabbit hole, but wanted just to pick at this -
It's one of the things that is ... used as evidence ... but isn't quite correct. In a lab (and this is all Ben Bikman, he did the lab work but also the rebuttal to the way it was represented).

1 - in a lab - you can take adipose tissue cells and suffuse them in triglycerides, and show that this has an effect on the insulin receptors - which seems to indicate that fat makes fat cells insulin resistant. While this is true in a lab, the scenario just cannot happen in a human body. Triglycerides don't just float about, because they don't float - our entire lipid transport system evolved in order to chaperone fats in the form of triglycerides, and cholesterol about the body safely.

2 - in the body, it's actually the other way around - insulin resistance leads to those same adipose cells swelling up (hypertrophy) because that's what insulin does - tells those cells to take in fats and glucose and store them. Those cells swell up, causing inflammation and for triglycerides to break down into free fatty acids and leak from the cells.
 
In which case I'm happy to stand corrected! :)

I'm sure I've also read that high fat diets produce insulin resistance - or is this a similar case of mis-application of lab studies into a real-world setting?
 
SimonP78 said:
In which case I'm happy to stand corrected! :)

I'm sure I've also read that high fat diets produce insulin resistance - or is this a similar case of mis-application of lab studies into a real-world setting?
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It may be, but a lot of these "statements" are simply unsupported by facts, and are/were made with the aim of supporting the current official dietary advice - basically 'fat bad, carb good'. I can recall reading so much unreferenced/unsupported statementing in my early days that I stopped using "the internet" for info and went to printed sources.
 
I don't have a reference to hand, but recently saw a Nick Norwitz video about C15 (saturated fat) which mentioned that the only evidence about saturated fat and Insulin Resistance is that Sat Fat improves (i.e. decreases) IR rather than making it worse.
Certainly, if sat Fat was making my IR worse, then how did it put me in T2D remission at the very same time?
 
ianf0ster said:
I don't have a reference to hand, but recently saw a Nick Norwitz video about C15 (saturated fat) which mentioned that the only evidence about saturated fat and Insulin Resistance is that Sat Fat improves (i.e. decreases) IR rather than making it worse.
Certainly, if sat Fat was making my IR worse, then how did it put me in T2D remission at the very same time?
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Consider me duly corrected, I shall strike "fat produces insulin resistance" from my parroting list ;)
 
I agree that the UK Daily Mail is not the most reliable source of facts
and figures, and often goes for the shock headline. It's been criticised
for its unreliability; its printing of sensationalist and inaccurate scare
stories about science and medical research.

Having said that though, it's important to check out accredited medical
opinion in order to confirm or discredit what the Daily Mail often reports.

Professor François R. Jornayvaz is the Chief Medical Officer of the Department
of Endocrinology, Diabetology, Nutrition and Therapeutic Education of the
Hôpitaux universitaires de Genève. He is also an Associate Professor at the
Faculty of Medicine at the University of Geneva.

He states, of Inchauspé: "She hides behind a pseudoscientific appearance to advocate
a method which, in my opinion, doesn't work and is based on very little evidence.
The scientific studies she cites are highly anecdotal, if not outright false, or not
applicable to what she proposes".

So... do we accept the claims of the self-styled Glucose Goddess, or the research
of the highly qualified researcher professor Jornayvaz?

I'd also suggest people check out THIS site, hosted by Sophie Gastman, who holds
a First-Class BSc in Nutrition and Food Science, and is a Registered Nutritionist
(RNutr Public Health). Gastam weighs in on the science behind Inchauspé’s claims.

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