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GAD came back negative

Antje77

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21,522
Location
Friesland (the Netherlands)
Type of diabetes
LADA
Treatment type
Insulin
Got my C-peptide result last month, which came back below normal (0.29 nmol/l non fasting with a bg of 6.1) and today my anti-GAD test came back negative.
Pretty inconlusive, I'd say, although it increases the chances of having T2.
Next week the internist who ordered the tests will call me. Let's see if she wants to do more testing for other antibodies or even for MODY, or if we decide things are going quite well and leave it be.
 

Very frustrating for you. Shouldn't c-peptide tests be done fasting? I have no idea, but actual insulin production tests are.
 
My GAD & islet antibody tests also just came back as negative, leaving T2 & Mody as possible diagnoses according to my endo - I doubt treatment would differ between the two.
For me the genetic aspect of Mody is interesting, but fairly irrelevant as a) Im beyond the age where Im going to have any kids and b) I’ve managed to keep diabetes under strict control for over 20 years on minimal meds - so a change in diagnosis wouldnt really bring anything new to my personal party
 
Bluetit1802 said:
Very frustrating for you. Shouldn't c-peptide tests be done fasting? I have no idea, but actual insulin production tests are.
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Apparently they take in account your actual bg and it still works.

Logically thinking, I'd say that when it's still low, even not fasting, it's even more proof you don't make a lot of insulin, but that could well be mis-thinking on my part
 
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Boo1979 said:
a change in diagnosis wouldnt really bring anything new to my personal party
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For me, a change in diagnosis might mean funding for the freestyle libre in the future. It might also be relevant for treatment choices in the future.
For now, it really doesn't matter as I do not fit the Dutch criteria for funding at the moment, regardless of type, and treatment (basal/bolus regime) works just nicely for me so no reason to change that.

Still would be nice to know, though
 
Antje77 said:
Apparently they take in account your actual bg and it still works.

Logically thinking, I'd say that when it's still low, even not fasting, it's even more proof you don't make a lot of insulin, but that could well be mis-thinking on my part
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Not mis-thinking. Some say for the c-peptide test to be any use one should have eaten, and the bg should be tested at the same time as the c-peptide test. If one is fasting there is no reason for much insulin to be released.

Are you aware of this immensely long article by Jenny Ruhl on Mody?
https://www.bloodsugar101.com/mody
I have the impression it has been expanded since the last time I looked at it, doubtless because JR has herself now been diagnosed as possibly having MODY.
" I was first diagnosed with Type 2 Diabetes in 1998. Several years ago I discovered that I may actually have a form of MODY which is a genetic form of diabetes different from both Type 1 and Type 2."
https://www.bloodsugar101.com/about
 
Thanks! Will read tomorrow
 

Welcome back to the fold @Alexandra100
 


I hope you can help me as I had a c peptide test not fasting. I was told to eat the biggest meal of the day and do the test two hours later. The result was < 0.3 mmol of albumen/creatin. However I was already doing very low carb and had barely any carbs with that mean. Does that skew the results? Thanks [/QUOTE]
 
[/QUOTE]
Albumin/creatinin is something else altogether than C-peptide.
 
Albumin/creatinin is something else altogether than C-peptide.[/QUOTE]

Sorry wrong result
. Will go and get the other one!
 
Antje77 said:
Sorry wrong result
. Will go and get the other one!
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Don't forget to mention the units they are in.[/QUOTE]

I have just looked back at my results and not there. Looked at the email from the hospital and it just said “there is no evidence....,,”. I still think it’s a possibility that a very very low carb meal would make a difference if testing after two hours, although not sure if that would make it better or worse. Can’t get my head round it. I will pursue an exact reading.
 
Alexandra100 said:
Are you aware of this immensely long article by Jenny Ruhl on Mody?
https://www.bloodsugar101.com/mody
Click to expand...
I've only started reading and the first part is:
"
Up to 20% of people diagnosed with Type 2 diabetes are not overweight. If you are one of them, it's worth doing some research to make sure that you don't, in fact, have one of the forms of what are often called "Type 1.5" diabetes, forms of diabetes that many doctors do not know about.

There are two major kinds of "Type 1.5." The most common is LADA (Latent Autoimmune Diabetes of Adults) which is a slow-developing form of autoimmune diabetes. Though LADA is usualy considered a form of Type 1 diabetes, research suggests that it may have some genetic overlap with both Type 1 and Type 2 diabetes. You can read more about LADA HERE.

Another, far less common, cause for diabetes in thin people is one of a number of monogenic forms of diabetes which are lumped together under the name MODY."

I'll read the rest, but she seems to be under the impression that being fat somehow protects you from having both LADA and MODY. Not a good start.
 
Antje77 said:
I'll read the rest, but she seems to be under the impression that being fat somehow protects you from having both LADA and MODY. Not a good start.
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I don't think that is what JR means, as elsewhere she complains bitterly abut the fact that people who are over-weight are often not diagnosed correctly as LADA due to the common pre-conception that all T1s are skinny and T2s fat. Thanks for the useful summary. I hadn't realised how much the article touches on LADA. I shall now read it more attentively, as I think LADA is probably where I am headed. Having said that, I do agree with Dr B's contention that what matters is abnormal bg levels and working out how to lower them by whatever means it takes.
 
Just checking @Alexandra100 have you had an updated diagnosis yet? Previously you were displaying non diabetic numbers.
 
Diakat said:
Just checking @Alexandra100 have you had an updated diagnosis yet? Previously you were displaying non diabetic numbers.
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My A1cs have been, serially, 41, 37. 38. 38. Obviously it was the 41 that alerted me to the fact that I have a problem with my bg, and I didn't want to allow it to worsen. In fact in the US even an A1c of 38 is considered pre-diabetic, and a many research studies have shown that it is at the pre-diabetic level that a lot of complications start to build. After lowering my carb intake I was quite pleased with the A1c of 37, but to my dismay although I lowered my carb intake still further I seem to be stuck at 38. Except that I am now seeing worsening fasting and mealtime bgs, so I suspect my next A1c in June will be worse again. I am currently eating <10g carbs daily, so I have no room for manoeuvre there. I would be quite happy to describe myself as "pre-diabetic". To say, "I am not diabetic" would be misleading. Were I to return to the "normal" healthy Mediterranean style diet I used to enjoy, I would soon see A1cs in the pre or even full diabetic range.

[moderator edit.]
 
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My daughter only last week was told by her doctors surgery that her HbA1c of 42 was normal and that the pre-diabetic range is from 48 to 49 the problem is her doctor is also my doctor and I know that he knows that to be incorrect for a fact as we have on occasion discussed it.

Which to my mind means trust no one research and find out for yourself as you cannot always trust what you are told.
 

Was just reading this thread as I also had my peptide and anti body tests come back this week.

The c peptide had a note on it to say that ‘low levels for high blood glucose at the time’. And apparently the other anti bodies came back negative. So the GP called me to tell me that type 1 is ruled out.

They are now suspecting I may be MODY and want to do testing for this. The reason being I am only 26, have a bmi of 21 and in all other aspects I am healthy and active.

Would you know what the MODY testing involves at all?

I think my diagnosis at this stage is somewhat irrelevant as they are still treating me with insulin.

I’m hoping to get an appointment with my consultant by the end of the month
 
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