I'm on it - I've never had any problems with it. When I was briefly off it my HBAC1 was going up (my problem is steroid induced diabetes). Couldn't take metformin - the usual reasons! As I understand it Gliclizade basically kicks the pancreas into producing more insulin. The only thing you have to watch is that if you have had carbs it can quite significantly reduce your BS levels. I've been on it for the last year (I have lost 4 stone as well since diagnosis) with no problems.