Grape seed extract

Jamesuk9

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I found this study with impressive results and was wondering if anyone has any input?:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466453/

Results:

Results showed that postprandial plasma glucose concentrations at 15 min and 30 min after ingestion HC meal together with 100 mg GSE (5.33 ± 0.41 mmol/L and 5.62 ± 0.47 mmol/L, respectively) and 300 mg GSE (5.27 ± 0.29 mmol/L; 5.75 ± 0.44 mmol/L, respectively) were significantly lower than that of HC meal (P<0.05). There was statistically significant difference in the 2 h area under the glucose response curve between HC meal and HC meal plus GSE.

To add to this, I took 400mg GSE yesterday morning and noticed fasting levels around 0.5mmol/L lower all day yesterday but my evening meal numbers were significant.

Before eating at 8pm, I was fasting at 4.8 and after eating I was at 5.2 at 1 hour and 5.4 at 2 hours. I then went to bed and woke at 5.7 this morning.

I ate, 2 pork chops, 2 fried eggs, broccoli, cauli and carrots, a Lidl protein roll with butter followed by 4 strawberries with a large dollop of double cream, plus a glass of cabernet suavignon.

I would normally reach about 7.7 on 1 hour and around 6 at 2 hours on this kind of meal.

I am trying to establish if this was fluke, or if the results are significant so I am doing the same again today.

This morning I had no dawning, woke at 5.7 and an hour later before breakfast was at 5.4, again this is significant for me as I normally climb at least 1.0 after getting up. I took another 400mg GSE.


I ate a large handful of nuts with around 100g Greek yogurt and tested at 7.1 at 1 hour and 5.8 at 1hr 30.... Again this is significant for me as I'm very insulin resistant before about 3pm every day.

I'll be watching my evening meal numbers closely tonight.
 
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bulkbiker

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Sounds like a very interesting self experiment.. be interesting to see if today's results are the same. Good luck!
 
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Jamesuk9

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Sounds like a very interesting self experiment.. be interesting to see if today's results are the same. Good luck!
Thanks, certainly interesting. The curve charts in that study show significant post prandial effect in GSE treated participants.

Other studies I've read point to it as being more effective than metformin but as usual I approach these things with a big dose of scepticism until I can prove it works.
 

bulkbiker

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Thanks, certainly interesting. The curve charts in that study show significant post prandial effect in GSE treated participants.

Other studies I've read point to it as being more effective than metformin but as usual I approach these things with a big dose of scepticism until I can prove it works.
The only caveat I would say is that the subjects were all very young (low 20's) and in good health with BMI's in the "healthy" region so the results may not work so well with insulin resistant Type 2's with a few more miles on the clock.. Still a very worthy trial by your good self.
 

Jamesuk9

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The only caveat I would say is that the subjects were all very young (low 20's) and in good health with BMI's in the "healthy" region so the results may not work so well with insulin resistant Type 2's with a few more miles on the clock.. Still a very worthy trial by your good self.
Yes, I noticed that... That said, 3 months ago I was a metabolic mess and now am at BMI 20.8, 14% body fat and high BP has normalised through LC and exercise so am probably fitter than I was at 20 despite being 52.

I did take GSE for BP control last year before I started monitoring glucose so had it in the cupboard and thought I'd give it a go when I stumbled across this study.

Nothing else has changed other than the GSE for 2 days and I am definitely seeing lower numbers by some margin so I'm crossing my fingers.
 
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bulkbiker

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Yes, I noticed that... That said, 3 months ago I was a metabolic mess and now am at BMI 20.8, 14% body fat and high BP has normalised through LC and exercise so am probably fitter than I was at 20 despite being 52.

I did take GSE for BP control last year before I started monitoring glucose so had it in the cupboard and thought I'd give it a go when I stumbled across this study.

Nothing else has changed other than the GSE for 2 days and I am definitely seeing lower numbers by some margin so I'm crossing my fingers.

Great news.. I'm tempted to get some myself now.. please keep up the reports.. sounds like you are doing a great job.
 

Jamesuk9

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Will do, I know I tolerate it well from continuous use previously, this is the one I take from Amazon, it's important to be at least 95% opc for maximum effect apparently.

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Jamesuk9

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Great news.. I'm tempted to get some myself now.. please keep up the reports.. sounds like you are doing a great job.
So, tonight I went heavier on the carbs and added baked beans. Something I haven't eaten in over 3 months.

4 slices bacon, 2 eggs, 2 sausages, 2 slices corned beef, 100g baked beans, Lidl roll, 4 strawberries, 100g double cream, glass of red wine. Total 48.5g CHO.

Pre meal 5.1, 1hr 6.4, 2hr 6.0.

Certainly a lowering of my peaks again.

I'll keep testing.
 

Hpetal

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So, tonight I went heavier on the carbs and added baked beans. Something I haven't eaten in over 3 months.

4 slices bacon, 2 eggs, 2 sausages, 2 slices corned beef, 100g baked beans, Lidl roll, 4 strawberries, 100g double cream, glass of red wine. Total 48.5g CHO.

Pre meal 5.1, 1hr 6.4, 2hr 6.0.

Certainly a lowering of my peaks again.

I'll keep testing.
WOW if I ate that much I wouldn't be able to move haha:)
I am watching your results with interest, and off to the health food shop to buy some grape seed extract. thanks for the info.
 
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Resurgam

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It could explain why the seeded grapes I usually buy have less impact than the unseeded ones I bought when the seeded ones were not available - I chew up the seeds as it slows down consumption.