How long dose meds stay in system once stopped

One thing to be careful of if you are doing this without any medical input, is that stopping gliclazide suddenly can cause a rebound high which can be dangerous - Gliclazide is a drug where the dose is slowly increased (titrated ) in order to find the correct level and needs to be titrated down when stopping the drug.

Gliclazide's half life is 12 hours.


I recently stopped taking gliclazide and I noticed that if I went 6 hours w/o eating, my blood sugar will be in the mid 4's and no longer hypo. I haven't noticed any other differences in my blood sugars, but I also didn't find gliclazidr effective in reducing blood sugar to begin with. I was on the max dosage and still had high blood sugars (teens to 20s).

I never had any gastro issues with gliclazide, but my urine would smell like sulfur if I didn't drink enough water.

Talk to your medical team about discontinuing the meds. My doctors said I could half or discontinue completely when I started basal insulin. They never mentioned anything about needing to wean off or anything, but I don't know your medical history.

Boo1979 said:

One thing to be careful of if you are doing this without any medical input, is that stopping gliclazide suddenly can cause a rebound high which can be dangerous - Gliclazide is a drug where the dose is slowly increased (titrated ) in order to find the correct level and needs to be titrated down when stopping the drug.

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I stopped my gliclazide last month and my BG readings have shot up. I'm hoping its a 'rebound high' and starts to level off and perhaps fall in a week or so. My gliclazide was first reduced by 50% and I managed to keep BG within limits although there was an initial rise.