Interesting I'm up in the low 30s and I am quite dinky, not that sedentary. I remember when growing up they used to look at a unit for a kg (but that was YEARs ago). I do wonder whether time as your islet cells completely pack in and weight…and then whether other things like metabolism and other hormones can effect it and change dose levels - but I haven't researched any of that it is just thinking out loud! Oh and also climate - hot places and I definitely need less.