In the 1970s, when I lived in the north-east of England, the old timers swore blind that the brewery used to put something into the Newcastle Exhibition Ale, specifically to give you a hangover.
Although it was the "most secret of secret ingredients", the brewery's logic allegedly was that, if you didn't have a hangover the following morning you wouldn't believe that you'd had a proper drink the night before and you'd change to another make of beer. Magic!
(Mind you, I did see 70-year old ex-steelmen and -miners regularly put a dozen bottles of Newcastle Brown Ale, and more, down their necks in an evening (and sometimes even at a lunchtime session), and not turn a hair. They'd walk home as straight as a die and be back for more, the next time to pub opened. The amazing thing was where they managed to put it all. I'd swear not one of them was over 10 stones, dripping wet).
I'm not advocating that sort of drinking, BTW. I doubt if any of them survived beyond their early-70s - although other problems associated with those industries mainly saw to that).