is there cure for type 2 yet

loiphamp

Well-Known Member
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143
Type of diabetes
Treatment type
Other
Type 2 diabetes is estimated to affect more than one in sixteen people in the UK. Most of these are diagnosed, but there are still around half a million people who are unaware that the condition is affecting their body. When it is diagnosed, though, what can doctors do to stop it? Medication can regulate blood sugar levels, which counteracts the effects to some extent. But in a breakthrough study, scientists may have found a way to cure type 2 diabetes.
The different types of diabetes
According to the Medical Research Council, nearly four million people in the UK have diabetes. And the vast majority – around 90 percent – are suffering specifically from type 2 diabetes rather than type 1. Here’s the difference:
Type 1 diabetes: An autoimmune condition where the pancreas is damaged and cannot produce any insulin
Type 2 diabetes: A condition which develops largely due to a person’s diet and weight. The pancreas becomes unable to produce enough insulin, or the body’s cells fail to react to insulin
Some people are genetically predisposed to type 2 diabetes, but it is generally brought on by long-term overweightness – increasing in likelihood with age. And much like other weight-related diseases, doctors have so far only been able to recommend lifestyle changes to reduce its impact.
A bigger problem across the pond
While type 2 diabetes is a significant problem in the UK, over in the states it’s even worse. Around 1 in 11 Americans have type 2 diabetes. And a large amount of them are suffering specifically because of insulin resistance. Touched upon above, this is where the body’s cells cannot take in insulin as normal as opposed to insufficient insulin being produced.
This prompted researchers at the University of California to search for a treatment. The team thought there might be a specific enzyme that causes cells to become resistant to insulin. They hypothesised that LMPTP, found in the liver, was the enzyme in question. And they set out to tackle it.
Medical breakthroughs
With a drug designed to stop LMPTP interacting with cells, the researchers hoped they would be able to return cells’ insulin reception to its normal state. And they were right. Tests on mice found that a daily dose of the new drug wiped out the condition – effectively curing the mice without any side effects.
The drug now needs to be tested for human use. If safe, it could be a huge boost in the fight against one of the fastest growing diseases. This is just one example of the breakthroughs that are possible with new technology in laboratories. Read more about the latest laboratory technology and how it fuels new discoveries in the article ‘Advanced Temperature Measurement for Breakthrough Medical Research’.
 

Resurgam

Master
Messages
10,087
Type of diabetes
Treatment type
Diet only
Mice are not a good test subject for drugs to be used on Humans - this could be a total red herring like the rabbit research done to 'prove' that fats cause atherosclerosis.
It is also not a cure but a treatment - requiring a daily dose of the drug.
Personally I would rather stick to eating a diet low in carbohydrates than be medicated back to eating a 'normal' diet.
 
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Kristin251

Expert
Messages
5,334
Type of diabetes
LADA
Treatment type
Insulin
Mice are not a good test subject for drugs to be used on Humans - this could be a total red herring like the rabbit research done to 'prove' that fats cause atherosclerosis.
It is also not a cure but a treatment - requiring a daily dose of the drug.
Personally I would rather stick to eating a diet low in carbohydrates than be medicated back to eating a 'normal' diet.
Bingo!!! Again...
I am very insulin sensitive as well as carb sensitive. A very delicate balance.
 
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kokhongw

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Messages
2,394
Type of diabetes
I reversed my Type 2
Treatment type
Diet only
@loiphamp This is certainly interesting because LMPTP inhibitors specifically target insulin resistance. If successful and found to be safe, it may also be effective against a whole host of chronic conditions associated with chronically elevated circulating insulin/IGF1?

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2344.html
This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes.

https://www.newscientist.com/articl...ug-could-be-the-first-to-reverse-the-disease/
A daily pill
A daily pill that restores the body’s sensitivity to insulin may make it easier to control the diabetes boom in rich nations where obesity is on the rise. Stephanie Stanford of the University of California, San Diego, and her team have found that giving mice with diabetes a drug that affects insulin signalling restores their ability to control their blood sugar levels.

The drug was given daily, by mouth, and did not seem to have any side effects in the mice. The animals had developed the condition after a high-fat diet had made them obese.

The danger is of course there will be no need for dietary changes....and thus may still lead to beta-cells exhaustion...
 
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Robkww

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262
A bit of news does the share price or the award of research grants no harm - let's wait and see ....