Is this the end of the line?

[bulkbiker]

https://mcb.berkeley.edu/labs/krant...-SPRING2008-LECTURE7-METABOLIC_REGULATION.pdf

Epinephrine stops insulin storing glycogen and increases use of glycogen to provide energy in the cells. Insulin is still needed to keep the door open so blood glucose can enter the cell as well. So in effect it switches from storage mode to use mode. Remember that insulin is both the gatekeeper of the storage action, but is also needed for glucose burning. It turns the three-way valve to the next position in the boiler.

Seems to show that both epinephrine and glucagon have a regulatory impact on insulin.
I think Bikman's work is a bit more current though.. maybe?

 

[LaoDan]

As mentioned before, CICO is an over simplification. I was talking to HID about this, she studied Thermodynamics as part of her degree. The human body and weight loss or gain was never mentioned. The First Law of Thermodynamics applies to a closed system whereas the human body is not a closed system.

So, what does the demand side of the equation look like? Are you happy with the amount of lean body mass? Are you able to do some HIIT to light up the burners?

 

[Oldvatr]

Seems to show that both epinephrine and glucagon have a regulatory impact on insulin.
I think Bikman's work is a bit more current though.. maybe?

They both work but they are different in what they actually do,
http://www.bioinfo.org.cn/book/biochemistry/chapt22/bio4.htm


Krebs is old fashioned in that it only covers glucose transport mechanisms. Glucagon controls the use of lipids for energy so is more effective for hypo's where there is little or no glucose in the blood and the local glycogen has been used up (quite quickly). Glucagon is in a way the fat burning enabler.