Dr Charles Mobbs, who lead the study, said: "Our study is the first to show that a dietary intervention alone is enough to reverse this serious complication of diabetes". Encouragingly, Dr Mobbs also believes the diet could also help with related diabetic complications such as retinopathy and neuropathy.
Considering the extreme requirements of the diet, it is not a long-term solution in adults. However, Dr. Mobbs' research indicates that exposure to the diet for a limited period may be sufficient to "reset" the gene expression and pathological process leading to kidney failure.
The researchers also identified a large array of cellular stress-related genes expressed during diabetic nephropathy not previously known to play a role in the development of this complication. The team found that the expression of these genes was also reversed in the mice on the ketogenic diet.
Dr. Mobbs and his team plan to continue to research the impact of the ketogenic diet and the mechanism by which it may reverse kidney failure in people with diabetes, and in age-related kidney failure. He believes the ketogenic diet could help treat some neurological diseases and retinopathy, a disease that results in vision loss.
Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, MAY reverse impaired kidney function in Type 1 and Type 2 diabetes.
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