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Metformin and Linagliptin - cause hypos?

W

WGS

Newbie
Messages
1
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Hello Everyone,
I've been on Metformin for years and Linagliptin now for about 18 months. Recently I have been experiencing what I would consider to be symptoms of hypoglycaemia. My diabetic nurse said that it's not possible to go hypo from taking these two medicines together. Has anyone experienced hypos with these medications taken together?
 
WGS said:
Hello Everyone,
I've been on Metformin for years and Linagliptin now for about 18 months. Recently I have been experiencing what I would consider to be symptoms of hypoglycaemia. My diabetic nurse said that it's not possible to go hypo from taking these two medicines together. Has anyone experienced hypos with these medications taken together?
Click to expand...
This study says that 2% of people on the mixed drugs had hypos, none severe.
pubmed.ncbi.nlm.nih.gov

Initial combination of linagliptin and metformin compared with linagliptin monotherapy in patients with newly diagnosed type 2 diabetes and marked hyperglycaemia: a randomized, double-blind, active-controlled, parallel group, multinational clinical t

Linagliptin in initial combination with metformin in patients with newly diagnosed type 2 diabetes and marked hyperglycaemia, an understudied group, elicited significant improvements in glycaemic control with a low incidence of hypoglycaemia, weight gain or other adverse effects. These results...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

The study was on newly diagnosed T2s.
 
WGS said:
Hello Everyone,
I've been on Metformin for years and Linagliptin now for about 18 months. Recently I have been experiencing what I would consider to be symptoms of hypoglycaemia. My diabetic nurse said that it's not possible to go hypo from taking these two medicines together. Has anyone experienced hypos with these medications taken together?
Click to expand...
Do you have a blood glucose monitor?
Then you could test to see if you are going low.

The drugs are not designed to give people low blood glucose, but not everyone is the same. Maybe the likelihood is you are now needing a change in dosage or a change in meds. Have you had a recent hba1c levels test?

I would suggest a review with your doctor.
 
The gliptin family of drugs are dpp4 inhibitors.
It is to help with first phase insulin response, for those with insulin resistance or a weak first phase like me.
It helps improve the imbalance of insulin after food to lower the spike, with the carbs you can tolerate.
Hope that helps.
We are always learning.
Best wishes.

(mod edit of quote)
 
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