- Messages
- 4,396
- Location
- Suffolk, UK
- Type of diabetes
- Type 2
- Treatment type
- Tablets (oral)
- Dislikes
- Diet drinks - the artificial sweeteners taste vile.
Having to forswear foods I have loved all my life.
Trying to find low carb meals when eating out.
Having been pointed towards Blood Sugar 101 and Jenny Ruhl I find myself yet again confused.
https://www.diabetes.co.uk/diabetes_mody.html says "
Maturity Onset Diabetes of the Young affects approximately one or two per cent of people who have diabetes, and may often go unrecognised in its early stages.
It is a form of diabetes that develops before the patient reaches 25.
"
https://www.diabetes.org.uk/diabetes-the-basics/other-types-of-diabetes/mody says "
The key features of MODY are:
However https://www.bloodsugar101.com/mody says "
Until the mid 2000s, the MODY form of diabetes were thought to only appear in people under age 25. However, genetic studies where the family members of people diagnosed with MODY were given genetic testing turned up the fact that people carrying the MODY genes are often misdiagnosed as having Type 1 or Type 2 diabetes.
It was also learned that MODY can develop into full-fledged diabetes as late as age 50. The Klupa study, referenced below, found that in one kind of MODY diabetes developed in 65% of those who carried the gene by age 25 years and in 100% by age 50 years, so more than 1/3 of all people with this kind of diabetes do not develop it in youth.
"
The Klupa study looks at MODY 3.
Unfortunately the references above don't provide a numbered list, but the paper refers to "HNF-1α" and the UK references say "
So the most common form of MODY has been shown to present at up to age 50.
Given that it was originally held to present before the age of 25 this is quite a big shift, and might justify the statement "MODY has been shown so far to present at up to age 50".
It does look as though MODY isn't being considered for thin T2s who are diagnosed at up to 50.
This is causing me some mental indigestion.
I was overweight on diagnosis (but not obese) and have been a slim T2 for years now.
I was diagnosed at 57{and a half) but that doesn't seem an impossible distance from 50.
I was tested some years back and found to have some IR but low normal insulin level.
This doesn't quite fit the MODY profile (possibly) but it does seem to be within the realms of possibility.
One important thing is that MODY is genetic (although there are possible genetic causes for other types) so if a family gene causes late onset MODY then presumably the rest of the family should be tested.
All I would have to do is convince the surgery that MODY is a possibility and have a specialist genetic test.
I'm not feeling that this would be an easy ask.
Possibly a starting point would be c-peptide and GAD antibody tests which are more mainstream.
I could really do without this extra confusion at the moment!
https://www.diabetes.co.uk/diabetes_mody.html says "
Maturity Onset Diabetes of the Young affects approximately one or two per cent of people who have diabetes, and may often go unrecognised in its early stages.
It is a form of diabetes that develops before the patient reaches 25.
"
https://www.diabetes.org.uk/diabetes-the-basics/other-types-of-diabetes/mody says "
The key features of MODY are:
- Being diagnosed with diabetes under the age of 25.
- Having a parent with diabetes, with diabetes in two or more generations.
- Not necessarily needing insulin.
However https://www.bloodsugar101.com/mody says "
Until the mid 2000s, the MODY form of diabetes were thought to only appear in people under age 25. However, genetic studies where the family members of people diagnosed with MODY were given genetic testing turned up the fact that people carrying the MODY genes are often misdiagnosed as having Type 1 or Type 2 diabetes.
It was also learned that MODY can develop into full-fledged diabetes as late as age 50. The Klupa study, referenced below, found that in one kind of MODY diabetes developed in 65% of those who carried the gene by age 25 years and in 100% by age 50 years, so more than 1/3 of all people with this kind of diabetes do not develop it in youth.
"
The Klupa study looks at MODY 3.
Unfortunately the references above don't provide a numbered list, but the paper refers to "HNF-1α" and the UK references say "
- HNF1-alpha. This gene causes about 70 per cent of cases of MODY. It causes diabetes by lowering the amount of insulin made by the pancreas. Diabetes usually develops in adolescence or early twenties, and people with HNF1-alpha MODY generally don’t need to take insulin: they can be treated with small doses of a group of tablets called sulphonylureas (often used in type 2 diabetes).
So the most common form of MODY has been shown to present at up to age 50.
Given that it was originally held to present before the age of 25 this is quite a big shift, and might justify the statement "MODY has been shown so far to present at up to age 50".
It does look as though MODY isn't being considered for thin T2s who are diagnosed at up to 50.
This is causing me some mental indigestion.
I was overweight on diagnosis (but not obese) and have been a slim T2 for years now.
I was diagnosed at 57{and a half) but that doesn't seem an impossible distance from 50.
I was tested some years back and found to have some IR but low normal insulin level.
This doesn't quite fit the MODY profile (possibly) but it does seem to be within the realms of possibility.
One important thing is that MODY is genetic (although there are possible genetic causes for other types) so if a family gene causes late onset MODY then presumably the rest of the family should be tested.
All I would have to do is convince the surgery that MODY is a possibility and have a specialist genetic test.
I'm not feeling that this would be an easy ask.
Possibly a starting point would be c-peptide and GAD antibody tests which are more mainstream.
I could really do without this extra confusion at the moment!
