My experience starting Gliclazide - is it the drug for me?

TheJungleFour

Member
Messages
6
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Looking for some advice - I'm due a review with the Nurse in 4 weeks, but I was thinking of getting in touch with them sooner about my recent blood sugar levels. Any input appreciated.

Background - I live a very sedentary lifestyle and was diagnosed with Diabetes 4 years ago. I was put on Metformin but I had awful GI issues - even on the slow release. I don't think my blood sugar was well controlled - especially in the past 3-6 months. A month ago my bloods came back and the Nurse/GP were very concerned and suggested I go on Gliclazide and Mounjaro. I had a BMI of 35.6 at the time. Not sure what my hba1c was but I suspect it was dangerously high - living off fast foods and drinking full sugar coke on a regular basis.

Started in Gliclazide at 40mg 4 weeks ago, whilst I wasn't consistently checking blood sugar at the start - I observed some readings like waking up with 15mmol/L, settling to around 9mmol/L in the evening. With rises also observed after my mid-day/afternoon naps. I tried to make some changes to my diet for most days, but had a couple of binge days on takeaways/fast food. Was still eating a lot of carbs.

Increased Gliclazide to 80mg after a week and I was seeing 9-12mmol/L > in morning, and my bloods seemed to settle down after spikes quicker. Hitting around 6.5mmol/L in the evening.

A week ago I started being a lot more stringent on my diet and have been consistently eating 1000-1200 calories a day at roughly 50g fat, 50-70g carbs, 70g protein. I've cut all the rubbish out and the healthy type of foods and all my carbs coming from low-GI sources.

I've been capturing bloods every morning, before every meal and then 1 hour and 2 hours after every meal. From Monday I've been waking up between 4.5mmol/L-5.5mmol/L. Bloods 2 hours after meal around 4.1mmol/L - 5mmol/L - but in the past 2 days I've had two readings in the evening at 3.8mmol/L. I reluctantly had a chocolate hobnob biscuit to help raise it up. My boyfriend had never been so confused in his life, there I was - holding a chocolate biscuit and NOT wanting to eat it. Normally I'd devour an entire packet hours after them entering the house..

Also this week - had my first Mounjaro (2.5mg) injection Tuesday morning. Yesterday and today I lowered my Gliclazide back down to 40mg - in part due to reading how it can cause weight gain - and losing weight is my my primary goal right now.

I'd like to stick on Mounjaro as I hear it's very good with weight loss. I feel confident I can stick with my meal plan and I'd rather not go back to eating high carb foods.
I'm a bit worried if I tell the nurse about my results over the past few days that they'll take the Mounjaro and tell me to stay on Gliclazide instead?

But not sure how much I can expect my bloods to go up by if I stop Gliclazide altogether, even with eating a much healthier diet - I still have a lot of weight to lose - and that may not come off for another 3-6 months if going at a reasonable pace.
 

ianf0ster

Moderator
Staff Member
Moderator
Messages
2,665
Type of diabetes
Treatment type
Diet only
Dislikes
exercise, phone calls
The forum rules don't allow us to give medical advice or diagnosis. However, we can relate our own personal experience - unfortunately I have no personal experience of any diabetes medications having been a diet controlled Type 2 (now in remission) since my diagnosis nearly 6 yrs ago.
 

Chris24Main

Moderator
Staff Member
Moderator
Messages
1,022
Type of diabetes
I reversed my Type 2
Treatment type
Diet only
As said - we really cannot advise anything in terms of meds...

But - if you can get in touch sooner - 4 weeks is a long time; you have started a med regime, and then made some extremely positive changes in your diet, that are having an effect on your blood glucose level (that's great) - and it may already be that there is a mismatch between what you are eating and medicating. MAY BE - so you have every reason to get in touch, not as an emergency, but as an urgent matter to check whether you are still on the correct dose. The two meds do very different things. Good luck.
 

TheJungleFour

Member
Messages
6
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Update on this.. I've come off Gliclazide. I was continuing to drop into 3.0-3.9 range on 40mg. I've left a message for my Diabetic Nurse to let them know what was going on. Haven't heard back yet but I just did not feel safe on Gliclazide. My appointment to discuss progress is in a couple of weeks.

Last took one Monday morning. Feeling much more comfortable cutting back on carbs now without fear of going into a hypo. Already noticing some difference - today and yesterday I had low-carb meals for Breakfast and Dinner.. whilst on Gliclazide my bloods were dropping rapidly late on in the evening. Today they're hovering around 5.0mmol/l a few hours after eating my second meal of the day.

On Gliclazide I was avg. 5.2mmol/l. I am expecting a rise in my blood sugars at some point, but by how much I don't know? I assume it may be a few days if not longer for the drug to flush out of my system..

I also got the results of my previous HbA1c - 125 January 2025, 121 March 2024.
 
Last edited:
D

Deleted member 596235

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Yes...

Gliclazide half-life = 10.4 hours. Duration of action =10-24 hours.