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Nebido injections for low testosterone in type two diabetics

N

nardley

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Hi,
I have been type two for ten years now and take metformin, gliclazide,prioglitzone, simvastatin, thyroxine, ramipril, bendroflumethiazide and fluoxetine. I have recently been diagnosed with a low testosterone count which accounts for my lack of energy etc. lately. I have been prescribed 'Nebido' injections to combat the problem and will have an initial injection followed by another in six-weeks and then every twelve to fourteen weeks. Does anyone out there use this product and have they suffered any side-effects so far? Have the benefits of this drug solved the problems associated with low testosterone. I am 55 yrs. of age, still working and in reasonable health.
Thanks,
NSA
 
Re: Nebido injections for low testosterone in type two diabe

Sorry
i read your post, but don't know anything about this medicine.
Hana
 
Re: Nebido injections for low testosterone in type two diabe

Hello NSA and welcome to the forum. :)

Sorry but I have no knowledge of this either but wish you well and hope that it helps you - with NO side effects! :)
 
Re: Nebido injections for low testosterone in type two diabe

nardley said:
Hi,
I have been type two for ten years now and take metformin, gliclazide,prioglitzone, simvastatin, thyroxine, ramipril, bendroflumethiazide and fluoxetine. I have recently been diagnosed with a low testosterone count which accounts for my lack of energy etc. lately. I have been prescribed 'Nebido' injections to combat the problem and will have an initial injection followed by another in six-weeks and then every twelve to fourteen weeks. Does anyone out there use this product and have they suffered any side-effects so far? Have the benefits of this drug solved the problems associated with low testosterone. I am 55 yrs. of age, still working and in reasonable health.
Thanks,
NSA
Click to expand...


NEBIDO.......Testosterone Enantate

Here are the known side effects of this Drug:
Side-effects prostate abnormalities and prostate cancer, headache, depression, gastro-intestinal bleeding, nausea, vomiting, cholestatic jaundice, changes in libido, gynaecomastia, polycythaemia, anxiety, irritability, nervousness, asthenia, paraesthesia, hypertension, electrolyte disturbances including sodium retention with oedema and hypercalcaemia, weight gain; increased bone growth, muscle cramps, arthralgia; androgenic effects such as hirsutism, male-pattern baldness, seborrhoea, acne, pruritus, excessive frequency and duration of penile erection, precocious sexual development and premature closure of epiphyses in pre-pubertal males, suppression of spermatogenesis in men and virilism in women; rarely liver tumours; sleep apnoea also reported; with patches, buccal tablets, and gel, local irritation and allergic reactions (including burn-like lesions with patches), and taste disturbances.

The side effects are not compulsory of course........although one or two may be of advantage ! :wink:

Ken.
 
Re: Nebido injections for low testosterone in type two diabe

Bloody hell Ken..........

Sometimes the CURE sounds worse than the CONDITION......... :shock:
 
Re: Nebido injections for low testosterone in type two diabe

how are you getting on with Nebido?
I'm not diabetic but have been on Nebido for 18 monthes.I have to have the injections every 8 weeks to maintain my testosterone levels.I certainly know at the end of the 8 weeks levels are dropping,lack of strength,sweats,hot flushes,extremely short tempered,not sleeping and memory lapses.
You should be closely monitored for prostate problems.Except for the dead leg for 8 to 10 hours post injection not had any side effects.I have just been put on Simvastatin even though my colesterols level were ok,as I started to get cramp like pains in my legs,was told this was probably down to the Nebido causing my blood to thicken slightly.
To me Nebido has been a miracle haven't felt so good for a long time.
 
Re: Nebido injections for low testosterone in type two diabe

I am a 47 year old male, a Type II diabetic treated with Exenatide and Lantus injections. My Testosterone levels are very low and as a result have been having Nebido injections for the last 18 months. I am on a ten week injection cycle.

For me the results are non-existent and to no effect whatsoever. It has had no noticeable effect on my testosterone levels, which continue to fall, reducing from 8.1 nmol/l to 5.5 nmol/l (sorry if these are the wrong units, I focus more on the falling numbers).

As for side effects I am noticeably more "angry" and "moody", and my head hair is falling out. My facial hair growth has reduced noticeably and while I was never hairy on the body I seem to be less hairy than ever. My sleep patterns are shot to hell, and I do get the odd bouts of lower leg cramps, and night sweats. Additionally I have found my bowels have been "upset" since I went onto injections, and there is a lot more laundry to be done. The effect on my libido has been non-existent, and I have not had any of the positive side effects, my wife should be so lucky!

Any concerns raised with the GP are routinely ignored, and attempts to see the endocrinologist are sabotaged by my GP. I struggle to get the GP to take regular blood tests to monitor my testosterone levels and had to demand tests to get my PSA levels tested to see if my prostate gland was OK. The GP service is appalling, and there is no realistic chance of involvement or help from my GP.

The Hospital services are better, and the specific endocrinologist I see is very skilled and helpful, although I insist on seeing the same consultant for both diabetes and endocrinology to ensure a tied up level of service delivery.

I live within the bounds of the Hull and East Yorkshire Area Health Authority and I am not impressed. When I lived in the West Yorkshire area, specifically Bradford, my treatment regime, the courtesy, and the level of interest shown by the medical authorities was much better. If we could afford to move back to West Yorkshire I would be going purely for the improvement in medical care.

To present I have been tested for across my HPGA axis, my hypothalamus seems to be ok, my pituitary function seems to be impaired, my gonadal function is ok, and my adrenal glands seem to alright. I am going to have to insist on a scan of my head to check for tumours as all the results from various tests always come up inconclusive or contrary to previous results.

One disturbing side effect I, and others, have noticed in me is that my fight or flight reflex has vanished. On several occasions I have stood up to bullies and boors where previously I would have shied away from trouble. I have got up in a crowded coffee bar, walked across the room and told someone who was ranting at an innocent couple to sit down and behave like an adult, and when he threatened to throw my over the balcony laughed in his face and told him to try it. He sat down, I went back to my chair and everyone was looking at me like I'd just dismantled a bomb. Previously I wouldn't have behaved like that at gunpoint! But now things like that present no fear to me. That is not the only incident I've had, but probably the only one I'd care to repeat in a public forum.

I am very frustrated at the total lack of effect of the injection and worried about why my levels are being allowed to fall to dangerously low levels without any attempt to find out the reasons why!
 
Re: Nebido injections for low testosterone in type two diabe

EricTCat,
I disagree with you - Nebido has by your testament made a difference to you. Both physiologically and psychologically you have manifested some of the medications side effects and desired effects. You mention that you're seeing a Consultant Endocrinologist for your diabetes, why didn't he/she initiate Nebido treatment? They don't just specialise in dibetes treatment. Your GP sounds like he/she is periodically assessing, monitoring and I assume titrating the Nebido dose. Injected testosterone can be likened to being on an emotional roller coaster, because you experience all the peaks and troughs which can make you feel at times, hard done by. Topical testosterone i.e. Testogel can be an option which seems to be tolerated better if compliance is not an issue.

The fact is that diabetes is insideous it must be managed. Your doctor is managing your diabetes because it isn't currable. Low testosterone levels have been found to be a common factor in men with diabetes. Diabetes is still receiving a great deal of attention from medical researchers because the disease is not completely understood. Men with diabetes who have symptoms of low sex drive, weak erections, chronic fatigue, depressed mood, or osteoporosis are likely to benefit from testosterone therapy. In the case of comorbidity with diabetes, T therapy is benificial because it may slow some of the ravages of diabetes, this will be a primary concern of your clinicians. They have objectivity and you don't that's why no matter how knowledgable you are, you are the patient.

You must be monitored closely during testosterone treatment for the duration of its use. From the outset of treatment you should have been receiving regular 3 monthly reviews of your free and total testosterone levels until stable, full lipid profile, monitoring of LH and FSH, PSA, electrolytes, and glucose monitoring. Periodic digital examination by the GP and your report of symptoms confirms prostate enlargement, not just serum PSA. The whole point of administering testosterone is to get you back to a more acceptable serum testosterone value, which will be in the mid to higher end of the normal range. Quantification and trend are only apparent through periodic blood testing.

Synthetic esters of testosterone at best mimic natural testosterone. HRT is a crude application of a complex housekeeping molecule. The hormonal processes are subtle within the human body and while medical understanding is getting better, there is a lot that it doesn't know. The testosterone molecule produces psychological effects and physiological effects. Low testosterone males tend to be meek and retiring, lack lustre and unmotivated, fatigued and easily distracted. You sound like you have more purpose and steel these days, that's a positive!

You must read the patient information brochure that accompanies your medication. If you did you would know that increased irritablility (moodiness) and quickening anger are part of the hormone's activating effects (motivating). This too has to be monitored because frequent impulsive disinhibited and explosive anger is not normal. This is likely to be manifested with testosterone misuse, i.e. males with normal mid to high testosterone levels taking inappropriate doses of testosterone without medical supervision.

It's simplistic to assume that erectile dysfunction is driven purely by low testosterone levels, there are other causes and these have to be investigated too. Instead of getting frustrated and blue look at your options, why not go to another GP for a second opinion? If you're suffering recent leg cramps/weakness, new onset fecal or urinary incontinence then you should tell your GP because this requires further investigation.

If your GP has told you that your testosterone serum levels are not stable (decreasing), then was this discussed or referred on? Has a strategy been discussed with you? You sound like you're in the dark. These are questions that you should be asking your GP, not casting doubt on his competency to practice. If you are so dissatisfied and you attribute all the problems that you listed to Nebido, then why are you continuing to use the medication? You must remember that diabetes is a disease that inflicts damage to your body that isn't reversable. Treatment is unlikely to give 100% benefit and consequent total satisfaction. Diabetes is a slippery pole carefully discuss/consider your treatment options before you refuse any therapy.

I wish you all the best.
 
Re: Nebido injections for low testosterone in type two diabe

I am also type 2 (metformin) and also have low T, 5.1nmol and very low T3.

Was on Sustanon, then moved to Nebido and I can say no side effects at all and enjoying life again.

Been on Nebido for 9 months and regulary hitting 25-27 nmol. Lost weight as am cycling to work daily now, which was impossible before and my Metformin dose has been drastically reduced 4 tablets a day, compared to 6 before Nebido.

Absolutely wonderful drug (for me) and enjoying life to the full again. I hope you find the right drug, personally its helped me. The injection is alittle more painful though...

Regards

Darren
 
Hi All
I'm on Nebido. Had the 6 week loading injection a few weeks ago. I feel dreadful. My "T" levels were 2.5 nmol. Real low. I ache all over with joint pain all over . I was on Tostran 2% gel for a short while and changed for the convenience of having one injection every 10 weeks. What a big mistake. I was using 3 squirts on each inner arms of the Tostran 2% Gel (60mg) each day. After 5 days I couldn't believe it. Woke up actually feeling rested without the usual feeling that I'd been run over by a steam roller. Over the next week my energy came back and strength. I was able to cope better with all my ill's (Type 2 Diabetes, Polymyalgia , migraine... the list goes on you get the picture) I'd been suffering severe side effects of low "T" for I guess 10 years and it took me paying privately for blood tests and the Gel and a change of GP practise for me to get help on the NHS. I really regret the change to Nebido for all the extra suffering it has caused. I'm back to square one again. The Gel , athough a pain to remember everyday increases the "T" levels by a greater amount and much much quicker than the Nebido does if at all. Google Nebido v Tostran 2% and you'll see a few studies on it that I wish I'd read before changing. Even my eye sight improved on the Tostran amongst better memory , skin and a whole host of other small changes. I was only on the Tostran for a month . As I said I couldn't believe the change. Get your levels right and it should make a huge difference.

Kind regards all.

Pete
 
watkins247 said:
I have just been put on Simvastatin even though my colesterols level were ok,as I started to get cramp like pains in my legs,was told this was probably down to the Nebido causing my blood to thicken slightly.
Click to expand...
I wonder why you'd be given a statin if your cholesterol is OK? Because of cramp like pains in your legs? It is a well known fact that statins not only prevent the production of cholesterol but something called Co-enzyme Q10 (CoQ10). CoQ10, an oil-soluble, vitamin-like substance present primarily in mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. This causes muscle pains, especially in the legs, in a lot of people. I say well known because Merc pharmaceutical actually applied for a patent in 1990 (yes, nearly 25 years ago) for a statin tablet containing CoQ10. In their words "to prevent impending muscle pain".
Even the poll on this forum suggests that 65% of people on statins have significant side effects. Hopefully you're not one of those who have side effects. Muscle pain is the worst, lack of sleep and brain fog seem to be common as well.
 
nardley said:
Hi,
I have been type two for ten years now and take metformin, gliclazide,prioglitzone, simvastatin, thyroxine, ramipril, bendroflumethiazide and fluoxetine. I have recently been diagnosed with a low testosterone count which accounts for my lack of energy etc. lately. I have been prescribed 'Nebido' injections to combat the problem and will have an initial injection followed by another in six-weeks and then every twelve to fourteen weeks. Does anyone out there use this product and have they suffered any side-effects so far? Have the benefits of this drug solved the problems associated with low testosterone. I am 55 yrs. of age, still working and in reasonable health.
Thanks,
NSA
Click to expand...
Please forgive me if I appear rude, it is not my intention, I would love to help but have no experience of Nebido. I'm assuming that testosterone levels have been measured, but I wonder if it might be related to the cocktail of meds that you take already. Just a thought.
I see that Pioglitazone has been withdrawn in some countries, I used to take a relative, Rosiglitazone, until it screwed up my liver function, no longer available in the UK I'm pleased to say.
Statins are well known for preventing the production of CoQ10 and in turn the production of energy in muscles.
Metformin has been associated with an excess of lactic acid in muscles making you feel like you've run a marathon every day.
Fluoxetine has been known to cause tiredness.
I think I would sit down and look at the side effects of everything that I took, including non prescription drugs (soluble cocodomol causes fluid retention). As has been said somewhere else, side effects are not compulsory, but it does make you think. I always seemed to end up taking something to overcome the side effect of something else.
I'm a bit more in control now, just by changing my diet. I cut out bread/pasta/rice/potato which allowed me to stop taking Gliclazide, Januvia and Atorvastatin because my BG and total cholesterol were all good without taking the pills. Cutting down on soluble cocodomol (arthritic knees, muscular spasms in back and sciatica) meant I was able to stop furusamide.
It's never easy, I hope you find a suitable resolution,
 
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