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Neuropathy

Alison556

Member
Messages
20
Hi all,

I registered a while ago and can't remember if I introduced myself!! :oops:

My name is Alison and I registered for my gran, who is 84 and was diagnosed with type 2 diabetes just over a year ago - although I suspect she had been suffering from it for a long time before that. I had a gut feeling she had diabetes with all the symptoms she had been describing and eventually I managed to persuade a locum GP to test her. At the same time, her gastro consultant informed us that her blood sugars had been consistently high for over a year (and nobody at the doctor's surgery thought to mention it!!).

Anyway, she started off on Metformin but it didn't particularly agree with her and it upset her ulcerative colitis. She was changed to Gliclazide 40mg in the morning and 40mg in the evening. This seemed to be suiting her much better, but on her review at the diabetic clinic, they changed her to Diamicron MR 30mg in the morning only.

Recently, she has been experiencing excrutiating pain in both her hips, across the small of her back and down her legs. She cannot stand for any more than a couple of seconds without being in excrutiating pain. She says it's extremely painful in bed and it's extremely painful when walking. The biggest problem is just standing still. She's almost crying it's so sore. She also says that it feels like there's a tight band round the tops of her legs. She's also complaining of constant pins and needles in her hands. She also says that her feet feel funny - kind of dead and it's like she's walking on stones or sand or something.

The GP sent her for x-rays and said that there was signs of arthritis in both hips and "wedging" on her spine and also slightly thinning bones.

Without any other examination, he said she has diabetic neuropathy and prescribed her Gabapentin 300mg, three times a day. She's been on it for two weeks and it's made no difference to the pain, but is making her extremely tired and disorientated - to the point that she'd rather not take them. She also has Co-Codamol and Tramadol painkillers but they aren't doing anything for the pain.

Does it sound like she has neuropathy? If so, is there any other treatment we can try other than the Gabapentin - that maybe doesn't have such horrible side effects?

I'd appreciate any help - it's awful seeing her so distressed. She's a very active lady and this is really depressing her and getting her down.

Many thanks,

Alison;
 
:( that sounds awful. Unfortunately, I have no clue as to what could be the problem. I think Neuropathy feels like sharp pains. It can also lead to IBS and eye sight problems.
But I am certain that someone here will be able to help :)

I do hope you get something sorted - it's horrible watching someone you care about in pain. Give your nan a hug from me.
 
Hi,Alison,welcome to the forum. Is your granny on Simvastatin by any chance? One of the side effects of this can be leg pain.Has she told her doctor about the side effects she is having? He may be able to change her onto something else. Gabapentin does have some really unpleasant side effects especially if you 're put on a large dose to start with.Get her to go back to the doctor and see if he will change things.
 
Hi and thank you for the quick responses.

Yes, she is on Simvastatin and I did read the leaflet that it could cause leg pain and she has had pains in her legs for ages, but in the last few months, they've got a lot worse. Can it do that? Make the pain get worse and worse the longer you take it?

The doctor started her off on just 100mg per day of Gabapentin, then put the dose up to 300mg on day one, 600mg on day two and now the 900mg - basically what it says on the leaflet.

I must admit, I have niggling doubts about the Diamicron. I reckon that she's been having more problems since they put her on that. I'm trying to persuade her to go back to the Gliclazide for a couple of weeks to see if there's an improvement in things, but she's not keen to go against the doctor.

I'm going to take her back to the doctor, hopefully Tuesday since tomorrow's a holiday.

Just for your information though, she is on loads of meds - Digoxin, Prednisolone, Azathioprine, Simvastatin, Warfarin, Frusemide, Actonel (for her bones) and calcium, as well as her diabetes meds.

Thanks again,

Alison
 
Just had a quick look at side effects.Back pain is mentioned but it is not a common side effect. Do you have a patient information sheet with her Diamicron? Also three of her tablets she is already on can interact with the Diamicron.Prednisolone,warfarin and furosimide.Now I'm sure her doctor already knows this but it is another thing worth discussing with him.
 
I've just noticed in your post that you refer to going back to Gliclizide from Diamicron but they are actually both the same thing!Diamicron is a trade name for Gliclizide.
 
Yeah, I've just got the patient information leaflet out.

I know that Diamicron is only a slow release version of Gliclazide (which she was on before) but I don't think we have the same control over her blood sugars as we did when she was on the plain Gliclazide. I have been a bit lax in checking her blood sugars recently because her fingers are so sore and I don't want to keep stabbing them! As an average though, her BSL first thing in the morning is normally about 6.2 (though it can be as much as 8.7) and by just before dinner, it's anything between 7.3 and 15.6.

One really weird thing I've come across. If she's a bit late with her lunch, she'll start to show all the symptoms of being hypo - pale, clammy, shaky, feeling sick and feels better after she's had something to eat - but I've checked her blood sugars during these turns and one day we were out, she felt like that and her blood sugar was 11.2. Because we were out and weren't near anywhere to get her something to eat, I gave her a sweet to suck on. Checked her blood sugar half an hour after the sweet and it was 11.1. An hour after the sweet, it was 9.1!!! There's either something wrong with her, or something wrong with the monitor!
 
sugarless sue said:
I've just noticed in your post that you refer to going back to Gliclizide from Diamicron but they are actually both the same thing!Diamicron is a trade name for Gliclizide.

Sorry, cross posts! Yeah, I know they're the same thing - the difference is the Diamicron is a slow release formula that she only takes once a day, as opposed to the two doses she used to take of the plain old Gliclazide. I don't know if it makes any difference...........
 
Oh! You've got me there Alison.Not being on any meds (so far)I'm a bit unsure of their actions.However it would sound as if the slow acting stuff is not working efficiently to keep her blood sugar levels on an even keel.That's another thing to discuss with doctor.Are you going with her to see the doc? Maybe writing down all these questions could be a good idea.
 
Simvastatin neuropathy is the killer for muscle pain. I had crippling muscle pain, saw a letter in the Balance mag & immediately stopped taking it. Within a week the pain had gone. What is called diabetic neuropathy could be Simvastatin neuropathy.

Obviously I cannot comment on her heart condition or know whether there is a specific reason for a cholestrol reducing drug being prescribed. However it is highly unlikely that she would suffer from cholesterol problems within the time it takes to notice relief from the pain. Tell her Dr if she stops taking it.
 
Thanks for the replies.

I think I'm going to cut her Simvastatin out as a starting point to see how it goes.

I'm not even sure that she needs the Simvastatin - the doctor put her on it because he said diabetics can have problems with high cholesterol! When her cholesterol was checked, her overall level was just over 5, but if you broke it down into HDL and LDL, the HDL level was quite high and the LDL was quite low (if I've got that the right way round), so really, it wasn't bad cholesterol that was high, but good.

Do you think she'd see any kind of difference in a week of not taking the Simvastatin?
 
Well according to Ian she may and he's had experience of statin pain.See how it goes,be careful how you tell the doctor these things,some of them can get quite snappy if you take decisions on your own!
 
Her doctor's a bit on the limp side. Most of the time, he doesn't seem to know what he's doing, then every now and again, he astounds us with some gem of knowledge that actually makes us think that sometimes he does know what he's doing!!

I'll be gentle with him though!! :P
 
This article explains all.

I'm now 69, 10 year diabetic, & generally fit & active. I play tennis at club standard. After a few months on statin (to reduce my chol from 5 to 4) I developed intense pain in my right thigh when trying to get out of bed. I was OK lying straight, but I could not bend my leg.

Continuing statin would have ended my active life.
 
Notice how the "official line" is stated at the beginning:
It must be emphasized that these side effects are very uncommon.

Our Dr said less than 1 in 10,000 and it a husband suffered, it was statistically highly unlikely that the wife would.

In the next 3 paragraphs, the truth is stated:
It has been known for many years that statins as a group of drugs may cause muscle damage and a particularly serious side effect known as rhabdomyolysis.

What are the possible ‘muscular’ effects?
Aches and pains and muscular weakness are not uncommon side effects among people on statin therapy. A very few may develop more severe muscle toxicity.

How common are these effects?
In the many statin trials conducted in the past approximately 5 in every hundred patients complained of muscle discomfort.

A pharmacist friend confirmed muscle pain as a common side effect. I asked "Why don't they warn us?" "Because if they did, people would soon stop taking them!"

I wonder, is a supposed decrease in heart attack risk worth a high risk of intense pain & the end of active life???????

Incidentally, about 15 years ago we were screened for heart & diabetes risk. We were the English control group as we live in an immigrant area.

No indication of diabetes risk, nor heart attack. My cholesterol was 6.4, but my Dr said that was no problem as there were no other risk factors. When I was diagnosed with diabs it was 7.6. Diet reduced it to 5.0. It was only the new guidelines that caused the Dr to put me on statins, and his computer reduced the 10 year heart attack risk from about 18% to 15% if chol went from 5 to 3.

I'd rather stay healthy & active than be crippled by drugs.
 
hya,
i stopped taking statins for the same reason,i felt like id been scrunched up all night,some mornings i could hardly walk downstairs,my gp changed it to ezetimibe which works differently in your intestines rather than your liver,the bad side effects went almost instantly and my cholesterol dropped too,good luck
amanda
 
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