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Novavax vaccine Trial

Discussion in 'Type 1 Diabetes' started by ert, Oct 26, 2020.

  1. ert

    ert Type 1 · Well-Known Member

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    I just received the call. I'm having the health screen check on Saturday followed by the injection if I pass. Is anyone else on the trial? I feel like I've won the lottery. 300,000 have signed up for the original 5,000 places.
     
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  2. JaneC

    JaneC Type 1 · Well-Known Member

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    I signed up and was accepted but decided not to go ahead last week as there are quite a few long hospital visits involved over a year and with only a 50% chance of getting the vaccine rather than the placebo it didn’t seem worthwhile on top of all the other diabetic appointments we have. I really don’t know if it was the right decision though.
     
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  3. DCUKMod

    DCUKMod I reversed my Type 2 · Master
    Staff Member Administrator

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    All the best with that Ert.
     
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  4. becca59

    becca59 Type 1 · Well-Known Member

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    Am in awe of your bravery. Thank you!
     
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  5. mariefrance

    mariefrance Type 2 (in remission!) · Well-Known Member

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    Hi ert
    Kate Bingham, Head of the UK Taskforce has just been on TV (BBC) and she was saying she has just had here first injection as part of the Novavax trial. So you're in good company!
     
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  6. ert

    ert Type 1 · Well-Known Member

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    They called me in a day early so had the injection yesterday. I've had a strong reaction to it - pain in my arm at the injection site, terrible headache, fever, horrible muscle aches and pains, nausea - I hardly slept at all last night. My symptoms aren't easing with paracetamol. My blood sugars are high so I'm following sick day rules. I've never been more excited about feeling unwell.
    I'm starting to feel better, but my blood sugars haven't responded to my four-hourly corrections yet.
     
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    #6 ert, Oct 31, 2020 at 11:53 AM
    Last edited: Oct 31, 2020
  7. Mr_Pot

    Mr_Pot Type 2 · Well-Known Member

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    I think you can be pretty confident that you didn't get the placebo! I hope you are back to normal soon.
     
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  8. hyponilla

    hyponilla Type 1 · Well-Known Member

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    This sentence made me giggle. You're a hero at the frontier of science. I also hope you feel better soon. It will be interesting to see how long the symptoms last.
     
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  9. bulkbiker

    bulkbiker Type 2 · Oracle

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    Depends what the placebo is.. in the US trials I believe they used a meningitis vaccine so hardly saline.
     
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  10. Dr Snoddy

    Dr Snoddy Type 2 · Well-Known Member

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    Also, the placebo should contain everything except the 'active ingredient'. So suspension fluid, preservatives etc some of which could also cause reactions.
     
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  11. Mr_Pot

    Mr_Pot Type 2 · Well-Known Member

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    Actually the placebo is saline....
    Sodium chloride injection (BP, sterile), 0.9%
     
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  12. Fawbs89

    Fawbs89 · Active Member

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  13. KK123

    KK123 Type 1 · Well-Known Member

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    Wow, our very own blow by blow account and hot off the Press. Keep on posting if you can Ert! x
     
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  14. ert

    ert Type 1 · Well-Known Member

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    I had my first antibody test. It was negative, day 5. I'm starting to wonder if I imagined all of my symptoms. Or I have to keep the faith that on average it takes 14 days for most people to develop antibodies. And some people not until the second injection.
     
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  15. NicoleC1971

    NicoleC1971 Type 1 · Well-Known Member

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    Agreed. Bizarrely they use a different vaccine as a placebo and apparently vaccines for 1 virus tend to make you more susceptible to other viruses. Doesn't that skew the results in favour of the vaccine you are testing because the placebo group are more likely to get sick?
     
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  16. ert

    ert Type 1 · Well-Known Member

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    They need 100 people to get Covid-19 for the vaccine to be considered a success, hopefully from the placebo group. They're not recording symptoms, just testing to see if the vaccine gives you immunity. The placebo is just saline (unlike the Oxford), but some people supposedly react to it (in their imagination?)
     
    #16 ert, Nov 9, 2020 at 5:53 PM
    Last edited: Nov 9, 2020
  17. Mr_Pot

    Mr_Pot Type 2 · Well-Known Member

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    They are using saline as the placebo - see page 52 of the the Novavax trial protocol.
    They are however testing a subset of participants with flu vaccine in their other arm "to evaluate the safety and immunogenicity of SARSCoV-2 rS with Matrix-M1 adjuvant when co-administered with a licensed seasonal influenza vaccine."

    https://www.novavax.com/resources#protocols
     
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  18. ert

    ert Type 1 · Well-Known Member

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    Wow. You're more informed than I am, and I'm on the trial. :)
     
  19. NicoleC1971

    NicoleC1971 Type 1 · Well-Known Member

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    https://theconversation.com/coronav...important-to-know-whats-in-the-placebo-146365

    This explains why sometimes researchers (Oxford vaccine) use an actual vaccine rather than saline. As BulkBiker said that is meningitis and pneumonia given so that participants who get the placebo feel that they've been given the real thing and hence get a true 'placebo' effect alongside those who get the actual thing.
    Still if the minks have mutated the thing, that seems to make the vaccine even more ineffective. As Boris has just said not the bugle from the cavalry yet...
     
  20. Mr_Pot

    Mr_Pot Type 2 · Well-Known Member

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    How are the side effects now? Do you get to find out, at some point in the trial, if you had the vaccine or placebo ?
     
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