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Ozempic : does it reduced weight in diabetcs only because it suppresses appeite?

I

ittiandro

Member
Messages
19
Type of diabetes
Other
Treatment type
I do not have diabetes
I am 81, diabetic. My doctor prescribed Ozempic as a last resort because metformin, exercise ( a lot of it , including running , windsurfing, etc ) and correct diet have been unable to significantly decrease my A1C and, worse, to stop my weight increase , mostly around the belly as visceral fat.

In a few years my weight has alarmingly increased by almost 10 kg to 95 kg .( At age 50 or 60 I was about 75 kg).

After reading ALL that there is to be read about Ozempic and how it works, I decided that the few side-effects are perhaps worth the benefits: I had my first 0.25 mg last week. I am eager to see how it plays out in the next weeks.

Here is my question.

I understand that Ozempic causes weight loss only by inducing satiety, but I don’t’ think that appetite suppression alone can play a significant role in weight loss in my case, if at all, because, according to my dietician my diet is already very healthy both in terms of quantity and quality.

In fact I have eliminated bread and sugar and put more proteins in the mix. Lots of veggies, fruits, fish, yogurt, kefir…There is no room for further changes.

I also understand that Ozempic stimulates the production of insulin by the pancreas by mimicking the GLP-1 hormone and by doing so it prevents sugar from being stored as body fat, but how does it contribute to weight loss?



Thanks for your comments



Ittiandro
 
It also stimulates insulin production and slows down gastric emptying. If you improve insulin production then you likely move glucose to organs that need it first and less circulating in the blood and less sugar to be converted to fat.
Slowing down gastric emptying means you feel fuller for longer and less intake of food and for most people less carbohydrate and less sugar.
With weight loss then you have increased insulin sensitivity, so even better response to insulin and less sugar in the blood to be converted to fat.
 
ThanksI

It is true that one of the factors contributing to weight reduction with Ozempic is that it increases satiety and therefore we eat less, but I was wondering whether this benefit is not offset by the body slowing down metabolism accordingly.THis is a well-known draw-back of diets
 
My understanding of when drugs affect the desire for food, it is principally the hormones in the digestive system being involved - which is a crucial part of our blood glucose regulation system.
 
I have been on Ozempic pic for just over a year. It was great for my blood sugar bringing it down from 119 to 46. I also lost weight too I don’t know how because it didn’t make any difference to my appetite. I could still eat the same amount of food I was eating before.
 
Hi. You mention that you have the 'correct diet'? Does that mean reducing overall carbs? You mention reducing bread and sugar which is good but there may be other things such as sugar-loaded yogurt which are contributing to your weight gain and higher BS
 
Daibell said:
Hi. You mention that you have the 'correct diet'? Does that mean reducing overall carbs? You mention reducing bread and sugar which is good but there may be other things hsuch as sugar-loaded yogurt which are contributing to your weight gain and higher BS
Click to expand...
My guiding principle is moderation. . Being more royalist than the king doesn't make sense. Yes, I did substantially reduce carbs, by staying away from refined sugar, and bread, jam and honey, but I didn't think that a few sweetened yogurts would weigh very heavily on the negative side. Then should we stay away from fruits, too? THey contain sugar, too., although in a chemically different form. Where do we draw the line? My dietician works vety closely with my doctor. She knows my diabetic condition but she she doesn't see a problem with sweetened yogurts.. Anyway I'll probably switch to unsweetened ( natural ) yogurt because I don't dislike it.
Thanks

Ittiandro
 
Are you testing your blood glucose before and 2 hours after eating, or with a Libre sensor? If not, that can give you information which foods raise it.
 
There is information in this thread that may help answer your question regarding the mechanism of the GLP-1 medications such as Ozempic

C peptide test and Medication

I am thinking I may get a better response from a LADA forum. I have a quick question- If you are LADA, but previously treated as type 2, did you have to stop your medications before the C-peptide test? I want to do the C- peptide test and concerned GLP-1 agonist may give a false positive...
www.diabetes.co.uk www.diabetes.co.uk
 
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