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PET scan and type 1 diabetes
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<blockquote data-quote="catherinecherub" data-source="post: 1175783"><p>If you are suffering from stiff person's syndrome then I feel for you.</p><p>It is not well known but does affect people with other autoimmune disorder, i.e. diabetes Type1.</p><p></p><p>There is an explanation in this article which describes the symptoms.</p><p></p><p><a href="http://www.movementdisorders.org/MDS/About/Movement-Disorder-Overviews/Stiff-Person-Syndrome.htm" target="_blank">http://www.movementdisorders.org/MDS/About/Movement-Disorder-Overviews/Stiff-Person-Syndrome.htm</a></p><p></p><p>Stiff person syndrome (SPS), first described by Moersch and Woltman in 1956, is a rare progressive movement disorder characterized by involuntary painful spasms and rigidity of muscles, usually involving the lower back and legs. This results in a typical clinical picture of stiff-legged gait with exaggerated lumbar hyperlordosis.</p><p></p><p></p><p></p><p>Structural MRIs of brain and spine are usually normal. The exact cause of classic SPS remains unknown but automimmune mechanisms are suspected to have a role. Antibodies to the enzyme glutamic acid decarboxylase (GAD), have been detected and other autoimmune disorders such as diabetes, pernicious anemia, and thyroiditis occur more frequently in patients with SPS. 60-90% of classic SPS patients have very high anti-GAD titres, (usually over 20 nmol/l). Another important association is that of SPS with paraneoplastic syndromes. Mutations of the GLRA1 (glycine receptor) gene have also been identified to account for some cases of startle and limb stiffness.</p></blockquote><p></p>
[QUOTE="catherinecherub, post: 1175783"] If you are suffering from stiff person's syndrome then I feel for you. It is not well known but does affect people with other autoimmune disorder, i.e. diabetes Type1. There is an explanation in this article which describes the symptoms. [URL]http://www.movementdisorders.org/MDS/About/Movement-Disorder-Overviews/Stiff-Person-Syndrome.htm[/URL] Stiff person syndrome (SPS), first described by Moersch and Woltman in 1956, is a rare progressive movement disorder characterized by involuntary painful spasms and rigidity of muscles, usually involving the lower back and legs. This results in a typical clinical picture of stiff-legged gait with exaggerated lumbar hyperlordosis. Structural MRIs of brain and spine are usually normal. The exact cause of classic SPS remains unknown but automimmune mechanisms are suspected to have a role. Antibodies to the enzyme glutamic acid decarboxylase (GAD), have been detected and other autoimmune disorders such as diabetes, pernicious anemia, and thyroiditis occur more frequently in patients with SPS. 60-90% of classic SPS patients have very high anti-GAD titres, (usually over 20 nmol/l). Another important association is that of SPS with paraneoplastic syndromes. Mutations of the GLRA1 (glycine receptor) gene have also been identified to account for some cases of startle and limb stiffness. [/QUOTE]
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