The recent results of the DIRECT study show correlation between how much weight the participants lost and the percentage who have gone into 'remission' (86% in those who lost 15kg or more, 57% in those who lost 10-15kg and 34% in those who lost 5-10kg). Does the study also look at the fat in the pancreas in participants who have gone into remission ? If so that would perhaps further support Prof Taylor's hypothses that the fat in the liver and most importantly fat in the pancreas is the problem. Then efforts could be focused on how to get rid of that pancreatic fat most effectively, whether by intermittent fasting, low calorie diet, low carb, exercise regimes or a combination. I suspect they don't have the data due to the nature of the study being across multiple centres and the cost of doing the specialised MRI scans. Has anyone read the whole paper ?