These drugs have been tested for kidney health safety. Just recently it was declared safe. Only after having enough human data.... through usage (human guinea pigs). Humf! The thrush I experienced was horrendous after just get rid of 2yrs of it too. I tried numerous ways of tolerating it. The thrush luckily was enough of a warning sign that my body was stressed.. on it. My meter showed 7s steadily and remarkably and on very little insulin, I even thought at one stage with metformin being reintroduced I could have stopped insulin but Wham! The thrush stopped me in my tracks.... even on 2ltr at least if water throughout the day. It seemed the more I drank the worse the thrush! I feel I was close to DKA on canagliflozin but was never tested but luckily as I was on insulin therapy so I treated bgs appropriately on stopping this drug. I'm very confident with insulin medication. Not everyone would be so lucky. DKA affects the muscles too. My muscle strength has never been the same, nor bone and joint strength either. I've exceeded limitations on suing about canagliflozin damage but in all honesty I'd never sue my nhs endo specialist anyway. He is very very good at his job at fighting type2 diabetes. I support him. He has done me proud in keeping me safe. I couldnt ask for a better endo for my hormonal complications! They are thin on the ground.