I was on Metformin for several years and I never had an appetite and have always been slim. Metformin is an appetite suppressant and I never felt hungry but after a couple of courses of B12 injections, (Metformin is known to cause B12 deficiency) I thought I would stop taking the tablets for a few days. I am also on quick acting and slow acting insulin so it's not as if I would be left without any medication. Anyway, the day after I stopped taking them I actually felt hungry! Stopping it made no difference whatsoever to my sugar levels so when I told the diabetes nurse what I had done and asked if it would be OK to not take them she said to try it for a while and see how I got on and it's now around two years since I stopped taking Metformin. Regarding low readings, "Make four the floor" is a diabetes saying because although it's good to be low it doesn't take much to get too low. I kept striving for lows as I had read that high sugar readings are not good but was told by a diabetes nurse that low readings are advised for younger people to stop them getting complications but as you get older they want you to be running a bit higher. I'm 74 so my targets are 7-9 before meals and 10-12 before bed as they would much rather you were running a bit high than too low. Metformin apparently doesn't cause hypos but Gliclazide does so maybe that needs adjusting to avoid going too low. I certainly think that leaving out the Metformin is well worth a try.