Sitagliptin side effects-advice requested

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6
I posted sometime ago about my friend who is type 2, at the time she had stopped taking her metformin, due to severe gastro-intestinal side effects, she was getting spikes into the high teens and probably averaging about 9.5/10; her appetite has always been very poor which doesn't help.

Recently things have improved significantly, the advice I received here being very helpful, her overall levels tend to be in high single figures with the occassional spike into low-mid teens, she recently saw her consultant and he prescribed sitagliptin as monotherapy and told her that if that didn't work she would have to commence insulin.

She commenced the sitagliptin on Monday, unfortunately she on Wednesday she developed extreme side effects-swollen face, to the extent of blinding her, and breathing difficulties, particularly worrying as she is a chronic asthmatic, obviously the sitagliptin has been stopped but is to re-commence next Wednesday; what I would like to ask is, has any experienced these side effects and subsequently re-commenced the drug and was it successful the second time around.

Her previous experience of using insulin, whilst pregnant was horrendous for her and can only be described as neglect, I discovered by chance that although she was vaguely aware of a hypo she wasn't sure what it was, how to recognise it,or how to deal with it, I've dealt with that, she was left to inject alone, after a brief demonstration, for 8 weeks whilst waiting to give birth in a maternity ward, she still finds the memory traumatic.

Given her understandable fear of injecting again, which we will overcome if we have to, and her very poor appetite, there is a lot riding on the sitagliptin so any experiences would be very valuble,thanks everyone for taking the time to read this. (Unfortunately she doesn't want to join the forum so I'm the proxy)

Paul
 

cugila

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Scratching around here as there are only the following side effects listed for Sitagliptin.

Gastro-intestinal disturbances; peripheral oedema; upper respiratory tract infection, nasopharyngitis; pain; osteoarthritis; less commonly anorexia, headache, drowsiness, dizziness, hypoglycaemia, osteoarthritis

nasopharyngitis
Acute nasopharyngeal inflammation, often with keratoconjunctivitis.

A personal opinion here is that the breathing difficulties and the conjunctivitus may well have been down to the Sitagliptin as above. If it was then surely your GP should consider an alternative ?
You need to discuss this prior to going back on it.

Ken.
 
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Angiodema, exfoliating skin conditions, upper respiratory tract infections and nasopharyngitis are all recognised side effects of sitagliptin therapy.

I had the opportunity to discuss this with a pharmacist I know and she could find no reference to anyone developing tolerance to the drug subsequent to side effects appearing, in fact she felt that once sensitised the chances were that these would reccur.

Given my friends medical history I am ofthe opion that the drug should not be recommenced unless she is admitted to hospital for monitoring, otherwise she will alone at home with a 4 year child.
 

mclaren

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5
Hi Paul

Tell your friend to ask for the new drug Victoza. It helps weight loss and also helps high bolld pressure.

I have asked on the forum if anyone has asked for it yet

Regards Maria
 

cugila

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mclaren said:
Hi Paul

Tell your friend to ask for the new drug Victoza. It helps weight loss and also helps high bolld pressure.

I have asked on the forum if anyone has asked for it yet

Regards Maria

Hi Maria.

Not sure where you are from Maria ? This drug Victoza has not yet been approved for use by the American FDA even though it is designed and manufactured there by Novo Nordisk ?
See this report from 8th June 2009.
http://diabetes.webmd.com/news/20090608 ... han-byetta

I hasten to add that this report was written by 2 Novo Nordisk reresentatives, so it isn't actually un-biased ?

This drug has only in the last week or so been given marketing authorisation in the EU. As such it is not listed here in the UK and will probably not be for some time yet. So asking for it in the UK is not yet an option. It's name in the USA at present is Liraglutide. Name in the EU - Victoza.

It is a once daily injectable treatment to rival the well known Byetta (which is a twice daily injection).
About Victoza®
Once-daily Victoza® is the first human Glucagon-Like Peptide-1 (GLP-1) analogue developed for the treatment of type 2 diabetes. Victoza® works by stimulating the release of insulin only when blood sugar levels are high. Weight loss with Victoza® is attributed to the fact that it slows gastric emptying and leads to increased satiety after meals. Victoza® is naturally broken down in the body and does not require renal excretion.

Hope that helps.

Ken
 

hanadr

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At thee Diabetes "event" I attended last week, we were told that our PCT isn't allowing Victoza. You can bet they're not the only ones.
 

ShyGirl

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It's taken six months but I have realised that it causes severe constipation which led to having to cancel a hospital appointment earlier this year (I haven't given birth yet but the pain can't be worse than what I went through) to sort "things" out.

I have also read about links to Cancer but every medicine seems to have some major flaw.
 
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I thought I'd give everybody an update on this.

The doctor who told my friend to recommence the sitagliptin was the GP at her local surgery, he takes a special interest in diabetes, eventually I was able to persuade to contact her consultant before taking the drug again, she was reluctant as she didn't want to offend her GP but I prevailed.

Her consultant told her that under no circumstances was she to recommence sitagliptin and to do so could be extremely dangerous in her case, especially given the breathing difficulties she experienced within the context of chronic asthma, she was also informed that she was the second person to present with this side effect profile, at this particular hospital, this year.

She has an appointment to see her consultant at the beginning of August, he's on holiday until then, and she will probably start on insulin; she's dreading this but I'm hopeful that we can overcome her fears and get her stabilised at last.

Thanks for all your support and advise.

Paul