Slow reacting Novo Rapid Insulin

[ingerd]

I have had T1 diabetes for 34 years. Some years ago I was diagnosed with brittle (unpredictable) diabetes. Within the last months the insulin Novo Rapid seems to react very slow in me.
In the morning after I inject and eat breakfast, the sugar goes up to 11 - 12 until lunch. I have tried to change the long acting insulin Levemir, but it does not help. I eat the same as always, my movements are the same and I change injection site always. If I take a higher dose of Novo Rapid in the morning, it slams down to 2.5 - 3 in the afternoon. Novo Rapid should react in 20 to 40 minutes, but in me it does not. It is not because the insulin has got old, because I changed to a new vial, but same thing. Has anyone had the same experience ?

 

[tim2000s]

Based on what I've seen from the Libre, I find it very variable across different injections as to the delay on Novorapid.

Under normal circumstances, injecting subcutaneously, it can take, for me, between 30 mins and 1 hour to have an effect. Intramuscular, it's about ten minutes.

This can vary dependent on a number of factors though, including the amount of exercise I've done the previous day, which I've seen push insulin resistance up dramatically.

Are you sure your Levemir levels are correct? Basal requirements do change, and that can affect the way that fast acting insulins work. That can often be an issue in this kind of situation. It's worth using a basal test to ensure that it is not linked to that.

Also, how are you using Levemir? Is it being delivered once or twice daily? The new NICE guidelines state that the best control with Levemir is obtained through twice daily injections.

 

[Juicyj]

Hi - I had problems with Levemir, over time I was increasing my basal and didn't realise it at the time but it wasn't working effectively for me, it took about 6 months before I finally got my DSN to change me over to Tresiba which now works brilliantly, however I put on over a stone in the meantime due to taking increased basal amounts and QA correction doses.

It may well be worth discussing with your consultant/DSN to see if a change would help ?

 

[novorapidboi26]

that is strange............

how long are you waiting from injection until eating?

could there be digestion issues?

 

[ingerd]

Based on what I've seen from the Libre, I find it very variable across different injections as to the delay on Novorapid.

Under normal circumstances, injecting subcutaneously, it can take, for me, between 30 mins and 1 hour to have an effect. Intramuscular, it's about ten minutes.

This can vary dependent on a number of factors though, including the amount of exercise I've done the previous day, which I've seen push insulin resistance up dramatically.

Are you sure your Levemir levels are correct? Basal requirements do change, and that can affect the way that fast acting insulins work. That can often be an issue in this kind of situation. It's worth using a basal test to ensure that it is not linked to that.

Also, how are you using Levemir? Is it being delivered once or twice daily? The new NICE guidelines state that the best control with Levemir is obtained through twice daily injections.

Based on what I've seen from the Libre, I find it very variable across different injections as to the delay on Novorapid.

Under normal circumstances, injecting subcutaneously, it can take, for me, between 30 mins and 1 hour to have an effect. Intramuscular, it's about ten minutes.

This can vary dependent on a number of factors though, including the amount of exercise I've done the previous day, which I've seen push insulin resistance up dramatically.

Are you sure your Levemir levels are correct? Basal requirements do change, and that can affect the way that fast acting insulins work. That can often be an issue in this kind of situation. It's worth using a basal test to ensure that it is not linked to that.

Also, how are you using Levemir? Is it being delivered once or twice daily? The new NICE guidelines state that the best control with Levemir is obtained through twice daily injections.

Based on what I've seen from the Libre, I find it very variable across different injections as to the delay on Novorapid.

Under normal circumstances, injecting subcutaneously, it can take, for me, between 30 mins and 1 hour to have an effect. Intramuscular, it's about ten minutes.

This can vary dependent on a number of factors though, including the amount of exercise I've done the previous day, which I've seen push insulin resistance up dramatically.

Are you sure your Levemir levels are correct? Basal requirements do change, and that can affect the way that fast acting insulins work. That can often be an issue in this kind of situation. It's worth using a basal test to ensure that it is not linked to that.

Also, how are you using Levemir? Is it being delivered once or twice daily? The new NICE guidelines state that the best control with Levemir is obtained through twice daily injections.

Hi Tim2000s - Thanks for your advises. I take Levemir 2 times a day. I have tried to regulate the Levemir, but have not increased it. Maybe I need more, but I will make a basal test first.

 

[ingerd]

Hi - I had problems with Levemir, over time I was increasing my basal and didn't realise it at the time but it wasn't working effectively for me, it took about 6 months before I finally got my DSN to change me over to Tresiba which now works brilliantly, however I put on over a stone in the meantime due to taking increased basal amounts and QA correction doses.

It may well be worth discussing with your consultant/DSN to see if a change would help ?

Hi Juicy - yes I also think it is the Levemir which is wrong, but I will first try to make a basal test, before I change. to something else.

 

[ingerd]

that is strange............

how long are you waiting from injection until eating?

could there be digestion issues?

Before I took insulin 20 min to 1/2 an hour before, but now I take it 1 and 1/2 hour before. It helps - it is better, but not very practical. Yes it can be something with the digestion also. My Stomack nerve Nervus Vagus works too slow (because of diabetes), but slower digestion should react opposite - I mean then the insulin should work quicker. Yes it IS strange

 

[Alasdair]

I wonder if your levemir from the night before has the wrong dose/time and runs out before your next one takes effect?

I've also found that my novorapid does quite a lot of its work between 4-5 (6) hours which can be quite frustrating

 

[Adriana682]

I have had T1 diabetes for 34 years. Some years ago I was diagnosed with brittle (unpredictable) diabetes. Within the last months the insulin Novo Rapid seems to react very slow in me.
In the morning after I inject and eat breakfast, the sugar goes up to 11 - 12 until lunch. I have tried to change the long acting insulin Levemir, but it does not help. I eat the same as always, my movements are the same and I change injection site always. If I take a higher dose of Novo Rapid in the morning, it slams down to 2.5 - 3 in the afternoon. Novo Rapid should react in 20 to 40 minutes, but in me it does not. It is not because the insulin has got old, because I changed to a new vial, but same thing. Has anyone had the same experience ?

Hi, I'm 49 having diabetes on insuline for 9 years, I have same experience with Glargine; finish in hospital in my country Slovakia, my sugar was very high , using 3x a day novorapid, they find special disease call diabetic gastroparesis and give to me tablets call Donperidon, 1x tablet before each meal and trust me works perfectly, you should see your diabetic doctor and ask for advice, finger cross

 

[Adriana682]

Hi there..I'm having diabetic gastroparesis using 3x a day Donperidon my sugar is anyway sometimes jumping up and down, and when I use novorapid it's very abrasive to dropping sugar down. Maybe I ask doktor to change my daily insulin Novorapid? What do you think?