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Sulfonylurea group 

HICHAM_T2

HICHAM_T2

Well-Known Member
Messages
1,447
Location
Morocco
Type of diabetes
Type 2
Treatment type
Diet only
Dislikes
Nothing
Good day
In my country has become a very effective medicine I think it's from salfanyuria family

It is enough to take one pill in the morning
In fact a surprising drug

But I was not surprised when I learned that it did not last more than ten years

Is this true or is it just Internet stuff
 
https://www.diabetes.co.uk/diabetes-medication/sulphonylureas.html

The drugs stimulate the pancreas to produce more insulin.

However the light that burns twice as bright burns half as long.

So as far as I know you get higher insulin production for a while, but this can cause the pancreas to fail sooner than if you were just on Metformin.
 
salfanyuria increase inslin levels, this will result in increased insilin resistance and weight. Remember that some of the complication of type2 are due to high inslin levels.

However salfanyuria are cheap and it is quicker for your doctor to give out pills then to sort out your diet.
 
This group of drugs should not be prescribed unless the person has had an insulin production test. If they already produce enough (or too much) insulin, it is a waste of time and money, and can only add to insulin resistance and a burn out of the pancreas.

I wouldn't touch them unless I knew my insulin was insufficient.
 
Thanks a lot for reply I think Especially the second generation it is very strong
 
Ive been on them for over 21 years - I combine sulfonylurea with dietary restrictions - last hba1c was 40 and dose of my Sulfonylurea ( Gliclizde) was halvd. Medics are no longer sure if Im T2 rather than another varient of diabetes
 
Sulfonylureas are an excellent group of drugs for the right person. My dad has been on low dose gliclazide (80mg) for over 40 years with no increase in dose and excellent control. I started them last year on the lowest dose which is enough for me and combined with a lowish but not very low carb diet, has given me excellent control. I don't have insulin resistance I just don't make enough of my own. I guess if you are very insulin resistant they wouldn't work as well and you would have to take high doses which would increase your weight. As for weight gain this hasn't happened to me in fact I've lost at least a stone since starting them and was only 9 stone to start with!
 
Lally123 said:
Sulfonylureas are an excellent group of drugs for the right person. My dad has been on low dose gliclazide (80mg) for over 40 years with no increase in dose and excellent control. I started them last year on the lowest dose which is enough for me and combined with a lowish but not very low carb diet, has given me excellent control. I don't have insulin resistance I just don't make enough of my own. I guess if you are very insulin resistant they wouldn't work as well and you would have to take high doses which would increase your weight. As for weight gain this hasn't happened to me in fact I've lost at least a stone since starting them and was only 9 stone to start with!
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Yes, I agree. As long as there is no insulin resistance and also insufficient insulin production they work well.
If there is insulin resistance and enough insulin production, it is a different ball game.
 
Hi. The sulfonylureas stimulate the pancreas to produce more insulin and are not generally useful for T2s who may be producing too much already. As another poster has said a test for insulin levels should really be done first.
 
Daibell said:
Hi. The sulfonylureas stimulate the pancreas to produce more insulin and are not generally useful for T2s who may be producing too much already. As another poster has said a test for insulin levels should really be done first.
Click to expand...
Do you think this type of medication is not suitable for the second type?
 
hichamgsm said:
Good day
In my country has become a very effective medicine I think it's from salfanyuria family

It is enough to take one pill in the morning
In fact a surprising drug

But I was not surprised when I learned that it did not last more than ten years

Is this true or is it just Internet stuff
Click to expand...

You may find it helpful to read Dr Ralph A DeFronzo's paper. and his view :
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
http://diabetes.diabetesjournals.org/content/58/4/773

"At the level of the β-cell, only the TZDs conclusively have been shown to improve and preserve β-cell function (75,268) and demonstrate durability of control (167,168,260, 268–272). There is also evidence that the GLP-1 analogs can preserve β-cell function on a long-term basis (273–275). Nonetheless, the two most commonly prescribed drugs in the U.S. and throughout the world are the sulfonylureas and metformin, and neither of these drugs exerts any significant protective effect on the β-cell. This is a major concern, since progressive β-cell failure is the primary pathogenic abnormality responsible for the development of overt diabetes and the progressive rise in A1C (Fig. 2 and supplemental Fig. A1)."
 
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