I have a Frio wallet but never thought it worked very well, though this is from more than 20 years ago so perhaps they have improved, equally if there is no refrigeration and it's a reasonably dry climate they will be more effective than nothing.
Where and how are you travelling? When in Europe, Australia, the USA, etc., I use a mini cool bag and mini ice packs generally separated from the insulin by a bit of cardboard (though really the box probably enough separation). I'd always put everything in my hotel fridge at night if possible (and refreeze the ice packs or at least cool them down if no mini-freezer), otherwise I would top up with ice from the communal dispensers/bar/restaurants (and keep a supply of plastic bags to put the ice in, in the cool bag). As
@Lacuna says it can last 30-odd days without refrigeration, though I'd try to keep it as cool as possible.
I would also bin the whole lot when I get back home if I have any concerns about how warm it got en-route (trips to Australia especially) and make sure I have a new set of vials ready and waiting for me.