What I wanted to find out was whether tresiba should be split doses? I thought it lasted about 36 hours and was "flat" so didn't have peaks...seems that it drops me a few hours after taking it (about 9.30pm) and then higher throughout the day. Although, I've still got a lot of testing to do. But the morning lows suggest taking it all at once is incorrect.
Not sure about that graph - it can't possibly start that fastI'll just disagree slightly. There is some peaking if you look at the action profile for a single shot, (http://images.rxlist.com/images/rxlist/tresiba2.gif). The reported effect from Novo is that when you overlap consecutive days of jabs the combined effect is flat throughout the day though I don't see that from a simple overlay of the graph referenced.
I am not entirely convinced it is fully flat for myself, ie a dropping BG overnight and bolus not working as well as expected later in the day. I have seen mention of splitting the Tresiba elsewhere and I am giving that a go at the moment, ie 50:50 split 12 hrs apart, which does appear to be addressing the behaviour I was seeing on a single daily jab.
I will just add that any peakiness I have seen with Tresiba is still a huge improvement on the issues I was having with Levemir.
I'll just disagree slightly. There is some peaking if you look at the action profile for a single shot, (http://images.rxlist.com/images/rxlist/tresiba2.gif). The reported effect from Novo is that when you overlap consecutive days of jabs the combined effect is flat throughout the day though I don't see that from a simple overlay of the graph referenced.
I am not entirely convinced it is fully flat for myself, ie a dropping BG overnight and bolus not working as well as expected later in the day. I have seen mention of splitting the Tresiba elsewhere and I am giving that a go at the moment, ie 50:50 split 12 hrs apart, which does appear to be addressing the behaviour I was seeing on a single daily jab.
I will just add that any peakiness I have seen with Tresiba is still a huge improvement on the issues I was having with Levemir.
@robert72, You are right, onset of action is 60-90 minutes. The graph I referenced assumes that the subject has been on Tresiba a few days and therefore has reached steady state insulin concentration at hour 0 and then plots out the action profile over the subsequent 42 hours.Not sure about that graph - it can't possibly start that fast
So, only showing half the story@robert72, You are right, onset of action is 60-90 minutes. The graph I referenced assumes that the subject has been on Tresiba a few days and therefore has reached steady state insulin concentration at hour 0 and then plots out the action profile over the subsequent 42 hours.
The axis is for glucose infusion rate which I assume mirrors the insulin action to maintain a constant BG. I can aee how your question would relate if this were instead a graph of serum insulin concentration though.As I understand it tresiba is series of monomers and dimers linked together and it's these monomers and dimers rather than the long chains which are adsorbed by the body. It has such a long acting profile as it gradually breaks up the longer chains over time. I wonder whether this graph is more of a description of the rate at which the longer chains break up therefore become available rather than it's action profile? ??
The axis is for glucose infusion rate which I assume mirrors the insulin action to maintain a constant BG. I can aee how your question would relate if this were instead a graph of serum insulin concentration though.
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