I was diagnosed 13 years ago and by loosing several stone I have managed my condition with diet and exercise however following a number of personal issues in recent years I have been depressed. This was put down to the diabetes and I was prescribed metformin? Since starting the treatment I have gained more than half a stone and feel so tired I struggle to maintain my usual 3-4 hours per week at the gym. Does anyone know of any direct connection between metformin and weight gain. I have taken the drug for short periods over the past 13 years and on each occasion I have had the same problem?