This article will review the Atkins diet, compare it with current nutritional recommendations for type 2 DM patients, and discuss the possibility of adopting a modified version of the Atkins diet as an alternative viable dietary approach.
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A 16-week pilot diet intervention trial also demonstrated that a low-CHO, ketogenic diet can improve glycaemic control in obese type 2 DM patients (mean BMI 42), such that diabetes medications were discontinued or reduced in 17 of the 21 participants.19 However, to date there has been no randomized controlled trial in type 2 DM patients and health care professionals remain wary of their use, particularly as standard dietary advice from Diabetes UK does not support this approach.
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Modified CHO diets
Until long-term safety data are obtained for low-CHO diets, a compromise may be appropriate, with the use of diets with lower CHO and modest protein intake. Such an approach has been trialled in a small-scale study led by the South-West Clinical Diabetes Research Group.23 Obese type 2 DM patients (n = 102) were recruited and randomly allocated to follow either a CHO restriction diet or a low-fat diet; 79 completed the 3 month study, with similar attrition rates in each group. Weight loss was greater in the low-CHO group (−3.55 ± 0.63 vs. −0.92 ± 0.40 kg) and cholesterol: HDL-cholesterol ratio improved (−0.48 ± 0.11 vs. −0.10 ± 0.10 kg), despite a diet containing more protein, saturated fat and less fibre. On the basis of this, a two-year randomized controlled study of CHO-restriction versus a prescribed energy deficit diet, in 300 obese type 2 DM patients has been funded by Diabetes UK. The study is due to report this year, and will provide information regarding the long-term efficacy and any potential side-effects of a low-CHO diet in patients with type 2 DM.
A six-month interim report (abstract only) based on 259 type 2 DM patients revealed greater weight loss in the low-CHO group (−3.77(0.46) vs. −1.34 (0.32), p < 0.0005) with no deleterious effect on glycaemic control, other risk factors or renal safety.24
Conclusion
Overall, there is growing body of evidence that low-CHO diet intervention is more effective, at least in the short term, in reducing weight and improving insulin sensitivity without significant adverse cardiovascular effects. However, more clinical trials need to be conducted to assess the effectiveness of varying degrees of low-CHO diet on weight, glycaemic control, hypertension and lipid profile in patients with type 2 DM, to resolve current controversies.