Edwardia said:
Just wanted to mention the ACCORD study in the US. Studied more than 10,000 ppl.
Intensive insulin therapy for T2 was deemed to be Hb1Ac <6% and normal T2 insulin therapy 7 to 7.9%. Over the life of the study 203 of the T2 7 to 7.9% ppl died and 257 of the T2 < 6% ppl. Over 50% of the excess deaths (as they phrased it) were from heart disease. The intensive insulin therapy part of the study was therefore stopped in Feb 2008
Hi,
The ACCORD study has come up quite a lot; and is still raised as a reason not to lower one's HbA1c's by some health advisers.
Here is a response I did earlier:
The ACCORD study is a large U.S clinical study of adults with established Type 2 diabetes who are at especially high risk of cardiovascular disease.
Three treatment approaches were studied: (i) intensive lowering of blood sugar levels compared to a more standard blood sugar treatment;(ii) intensive lowering of blood pressure compared to standard blood pressure treatment; and (iii) treatment of blood lipids by a fibrate plus a statin compared to a statin alone.
Note, that the intensive lowering of blood sugars was not done by a low carbohydrate diet but was done by increased medication. Participants in the intensive group were more likely to be on combinations of drugs than participants in the standard group. For example, 52% of participants in the intensive strategy group were on three oral medications as well as insulin, compared to 16% of those in the standard group.
In its regular review of the available study data, the ACCORD DSMB noticed an unexpected increase in total deaths from any cause among participants who had been randomly assigned to the intensive blood sugar strategy group compared to those assigned to the standard blood sugar strategy group and stopped the intensive blood sugar strategy group element of the trial.
On the whole, the death rates in both blood sugar strategy groups were lower than those seen in similar populations. That is, although the death rate was higher in the intensive treatment group than the standard group, it was still lower than death rates reported in other studies of Type 2 diabetes.
The ACCORD participant treatment is scheduled to end in 2009, and researchers plan to report the final results in 2010.
[Source :U.S Department of Health & Human Services, National Heart Lung and Blood Institute web site -
http://www.nhlbi.nih.gov/health/prof/he ... .htm#trial].
To sum up then; it is an ongoing Type 2 study, the increased mortality is related not to tighter control but to the manner in which the tighter control was attempted (i.e. high medication), the intensive blood sugar strategy group still had a better mortality rate than non-control Type 2 diabetics.
If anything this demonstrates that increased medication is the problem rather than tighter control.
It's rather like saying if I chop off my own leg with a chainsaw I will reduce my bodyweight (to the tune of one leg) but then bleed to death. Therefore, it is very dangerous to reduce one's bodyweight. Nope; it's very dangerous to use chainsaws as a means of weight reduction, just like it's dangerous to use high meds to reduce blood sugar levels.
Dillinger