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My friend's 12 year old nephew has Polycystic Kidney Disease, as does his mother, and his grandfather who sadly died from the disease. Following a discussion about carbonated and caffeinated beverages, I wanted to learn more about diet for this condition. This article really surprised me, particularly this section of the article - (I bolded the specific reference to glucose, also the inhibiting effect of ketones on kidney cysts)...
The work appears in the journal Cell Metabolism. Additional researchers from the University of California, Santa Barbara; the University of Missouri; and the University of Alabama.
Source: UC Santa Barbara
Original Study DOI: 10.1016/j.cmet.2019.09.012
Ketosis, the underlying metabolic state of popular diets such as the ketogenic diet, and, to a lesser extent, time-restricted feeding (a form of intermittent fasting), has been shown in the Weimbs group’s studies to stall and even reverse PKD.
“The cysts appear to be largely glucose-dependent,” Weimbs explains. In people with the predisposition toward PKD, the continuous supply of sugar in the high-carbohydrate, high-sugar diets of modern culture serve to feed the growth and development of the fluid-filled sacs.
“Ketosis is a natural response to fasting,” Weimbs says. “When we fast, our carbohydrate reserves are very quickly used up. In order to not die, our bodies switch over to a different energy source and that comes from our fat reserves.”
The body, he continues, breaks down the fat reserves into fatty acids and ketones which then take the place of glucose in providing energy to the body. The researchers found that the presence of ketones in the blood stream in particular inhibits the growth of the kidney cysts. And with a steady supply, ketones actually acted to reverse the condition in their animal studies.
https://www.futurity.org/polycystic-kidney-disease-food-2188002/ “The cysts appear to be largely glucose-dependent,” Weimbs explains. In people with the predisposition toward PKD, the continuous supply of sugar in the high-carbohydrate, high-sugar diets of modern culture serve to feed the growth and development of the fluid-filled sacs.
“Ketosis is a natural response to fasting,” Weimbs says. “When we fast, our carbohydrate reserves are very quickly used up. In order to not die, our bodies switch over to a different energy source and that comes from our fat reserves.”
The body, he continues, breaks down the fat reserves into fatty acids and ketones which then take the place of glucose in providing energy to the body. The researchers found that the presence of ketones in the blood stream in particular inhibits the growth of the kidney cysts. And with a steady supply, ketones actually acted to reverse the condition in their animal studies.
The work appears in the journal Cell Metabolism. Additional researchers from the University of California, Santa Barbara; the University of Missouri; and the University of Alabama.
Source: UC Santa Barbara
Original Study DOI: 10.1016/j.cmet.2019.09.012