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any closer to new t2's 'types'

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Katiecampb254

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Hey,
Anyone know of any on going reasearch into new type 2 types? I'm 28 was diagnosed at 25 as was my dad his mother her father his mother. Saw my consultant last week who once again pointed out that my family history was striking. I was asked if I have ever been massively over weight, which I have not. My weight has always been up and down but I have never been 'huge' currently well controlled on 1g metformin twice a day hba1c is 40. I have been tested for MODY and LADA. My anxiety is for my children and knowing if they have inherited my genes that it is inevitable they will get this, much as it was inevitable for me. I would like to know if there is anything in the pipe line for a genetic testing, if anyone if aware? Not like I could prevent it, but help my children prepare. Right now it's about life style. I watched what this did to my grandmother her eyes, kidneys, limbs, brain and in the end her heart.
 
Hi. There are many genetic variations of diabetes caused by genes and there is a growing list of genes which are know to be implicated (Google it). Like you I have never been overweight and my symptoms were classic LADA. I had GAD and c-peptide done privately and although my GAD was negative my c-peptide showed I had little insulin. There are many causes of islet cell failure beyond GAD including viruses, pancreatitis etc. Hopefully you will be able to stay on tablets but if your BS rises despite low-carbing, other tablets can be added and then insulin which works well for me when tablets failed.
 
Katiecampb254 said:
Hey,
Anyone know of any on going reasearch into new type 2 types?
Click to expand...
@Katiecampb254
A fun course (for me) was Diabetes- a global challenge by Univ. Copenhagen. A MOOC run via coursera:
Each section will be covered by world leading professors in the specific areas:

  • Prof Thorkild Sørensen (Epidemiology of Diabetes and obesity)
  • Prof Jens Juul Holst (Physiological regulation of blood glucose)
  • Prof Allan Vaag (Pathophysiology of Diabetes and Genetic versus pre- and post natal aetiological factors in T2D)
  • Prof Thomas Mandrup (Inflammatory beta-cell destruction in diabetes)
  • Prof Torben Hansen (Genetic aspects of Diabetes)
  • Prof Bente Stallknecht (Physical activity and its influence on insulin resistance and diabetes)
  • Prof Ole Madsen (Stem cell based therapy of Diabetes)
 
Have a look at this publication from last year: http://care.diabetesjournals.org/content/36/4/1047.long

It's not research but a very good summary of the current state of the knowledge. They are still working on how the disease develops.

The genetic component, or rather components, tend to do with the tipping point between the non diabetic and diabetic states. Why for example can someone have a BMI of 40 and not have diabetes whereas someone with a BMI of 25 may have diabetes. In addition, those people who have a tendency to lay down fat in the liver are more likely to get diabetes. Why some people lay down fat in one place but not another appears to be something encoded at birth. It's to do with the distribution of lipocytes or adipocytes. They are in place at birth and swell or shrink according to the fat stored. However, you may as well ask why some people look different from other people. You can't do anything about this, other than not store too much fat. Moreover, some people are very unlucky and only need to add a little bit of fat which is stored in the liver and that kick starts the process.

When this is the cause, and in most cases of type 2, but not all, it is, if sufficient weight is lost, it can stop further damage. Also, some foods are more 'dangerous' than others. This depends on the person's own metabolism and what enzymes they produce. Humans produce different quantities of many enzymes, but again, everyone is different.

But, as you can't be expected to go around with a laptop working everything out, the best advice is eat healthily by avoiding highly refined carbohydrates, sugar, white flour, white rice etc and consuming more complex carbs such as wholegrains, brown rice etc and in smaller quantities, and being more active. That is enough to keep diabetes in check for many type 2s so it is still very good advice for avoiding it. Your main problame with children is, their own peer group pressures. Kids want to be like their friends an eating habits learned early stay with us unless actively worked upon.

fat_cells306x245s.jpg
 
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