librarising
Well-Known Member
- Messages
- 1,116
- Type of diabetes
- LADA
- Treatment type
- Insulin
To summarise what people are saying in the links I provided :
IF I'M GETTING IT RIGHT, FH is NOT a problem of HIGHER cholesterol/HIGHER LDL. It's a problem of LDL receptors, which don't allow LDL into the cells. This leaves normal LDL floating around in the blood in higher amounts.
If the cholesterol hypothesis is rejected, then statins don't make sense. I'll leave Zoe Harcombe to conclude :
"If raised LDL is a symptom and not the problem, any cholesterol lowering medication would only make things worse. If LDL not getting to cells is the real harm of FH, then any attempts to lower cholesterol will make things worse. We know from the brilliant book by the Yosephs that cells will try to produce cholesterol if they cannot get it from the blood stream. We also know that brain cells produce cholesterol because of the blood brain barrier (which is why statins can have particularly harmful effects to mind, memory and mood). If people with FH are already suffering from LDL not getting to cells, then impairing the cell’s ability to make cholesterol will make things even worse.
People with FH should ideally be given medication (if anything existed) to stimulate cholesterol production within the cell, so that the cell would at least get the vital cholesterol it needs, even when it couldn’t get it from the blood stream."
Geoff
IF I'M GETTING IT RIGHT, FH is NOT a problem of HIGHER cholesterol/HIGHER LDL. It's a problem of LDL receptors, which don't allow LDL into the cells. This leaves normal LDL floating around in the blood in higher amounts.
If the cholesterol hypothesis is rejected, then statins don't make sense. I'll leave Zoe Harcombe to conclude :
"If raised LDL is a symptom and not the problem, any cholesterol lowering medication would only make things worse. If LDL not getting to cells is the real harm of FH, then any attempts to lower cholesterol will make things worse. We know from the brilliant book by the Yosephs that cells will try to produce cholesterol if they cannot get it from the blood stream. We also know that brain cells produce cholesterol because of the blood brain barrier (which is why statins can have particularly harmful effects to mind, memory and mood). If people with FH are already suffering from LDL not getting to cells, then impairing the cell’s ability to make cholesterol will make things even worse.
People with FH should ideally be given medication (if anything existed) to stimulate cholesterol production within the cell, so that the cell would at least get the vital cholesterol it needs, even when it couldn’t get it from the blood stream."
Geoff